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Like immunomodulators, biologics curb the immune system. But they are focused on the inflammation in your gut. These drugs target special proteins that play a role in inflammation.

Doctors use biologics if you have moderate to severe Crohn's that has not responded well to other medications. They also use it to treat open, draining fistulas.

Some examples of biologics are:

  • Cimzia (certolizumab pegol)
  • Humira (adalimumab)
  • Remicade (infliximab)

Side Effects of Biologics

Due to their targeted nature, biologic treatments tend to cause fewer side effects than other drugs used for Crohn's disease.

Your doctor will still want to monitor you carefully, though, especially for signs of infection. Although rare, lymphoma and a blood disorders may also occur.

Also, before taking biologics, let your doctor know if you have a heart condition or a disease affecting the nervous system.

You may have side effects at the injection site, such as:

  • Redness
  • Itching
  • Bruising
  • Pain
  • Swelling

Other possible side effects include:

  • Headache, fever, or chills
  • Trouble breathing
  • Low blood pressure
  • Hives or rash
  • Stomach or back pain
  • Nausea
  • Cough and sore throat