Ovarian Tissue Banking May Restore Fertility
Experimental Procedure May Help Women With Cancer-Related Infertility
March 8, 2004 -- An experimental new procedure that uses stored ovarian tissue may allow women to regain ovarian function and fertility, sometimes lost during cancer therapy.
A new report details the first successful use of cryopreserved (frozen and preserved) ovarian tissue which was re-transplanted to obtain functional ovarian tissue, and human eggs. The egg was successfully fertilized in the lab, to obtain an embryo.
Although the attempt did not result in a successful pregnancy, researchers say the results indicate that long-term banking of ovarian tissue can help women restore normal ovarian function and potentially allow them to become capable of supporting a pregnancy.
The study, conducted by Kutluck Oktay and colleagues at the Center for Reproductive Medicine and Infertility at the New York-Presbyterian Hospital/Weill Cornel Medical Center in New York City, was rushed to release today in advance of its scheduled March 13 print publication in the journal The Lancet.
Ovarian Tissue Transplant Produces Embryo
Experts say the new technique may allow female cancer patients women who undergo premature menopause caused by cancer therapy the same ability men have to preserve their fertility by freezing their sperm for later use.
"The life-saving chemotherapy or radiation treatments used for some kinds of cancers can result in infertility," says Marian Damewood, MD, president of the American Society for Reproductive Medicine, in a news release. "Unfortunately up to now, we have not been able to offer women the same ability to preserve their eggs or ovarian tissue that men have with sperm."
"With Oktay's work we appear to be much closer to the day when a young woman diagnosed with cancer can both survive the cancer, and subsequently have children," says Damewood.
In the study, researchers transplanted cryopreserved ovarian tissue into a 30-year-old breast cancer survivor who donated the tissue before her chemotherapy.
Within three months of re-transplantation, normal ovarian function was restored, as shown by the development of ovarian eggs and estrogen production. Twenty eggs were removed, and eight were suitable for in vitro fertilization with her husband's sperm.
Of those, one egg fertilized normally and developed into an embryo in early stages then was transferred to the woman's uterus.
The woman did not become pregnant, but researchers say the findings show fertility and ovarian function can be preserved in women through long-term ovarian tissue banking.
"Because the probability of pregnancy with one embryo originating from an in vitro matured oocyte [egg] is 6% to 12%, many attempts or simultaneous transfer of multiple embryos might be needed to achieve a pregnancy," write the researchers.