Using more than one medicine to prevent
multidrug-resistant TB. The standard treatment begins
with four medicines given for 2 months.
Continuing treatment for 4
to 9 months or longer if needed. The number of medicines used during this
time depends on the results of
directly observed therapy (DOT). This means visits
with a health professional who watches you every time you take your medicine. A
cure for TB requires you to take all doses of the antibiotics. These visits
ensure that people follow medicine instructions, which is helpful because of
the long treatment course for TB.
Trying a different combination of
medicines if the treatment is not working because of
drug resistance (when tests show that TB-causing
bacteria are still active).
Using one medicine to kill the TB bacteria and prevent active
The standard treatment is isoniazid taken for 9 months. For people who
cannot take isoniazid for 9 months, sometimes a 6-month treatment program is
Treatment with rifampin for 4 months is another choice. This is an acceptable
alternate treatment, especially for people who have been exposed to bacteria
that are resistant to isoniazid.1
Taking two antibiotics once a week for 12 weeks to kill the TB bacteria.5 For this treatment, a health professional watches you take each dose of antibiotics. Taking every dose of antibiotic helps prevent the TB bacteria from getting resistant to the antibiotics. The antibiotic combinations include isoniazid and rifapentine or isoniazid and rifampin.
recommended for anyone with a skin test that shows a TB infection, and is
especially important for people who:
Are known to or are likely to be infected
close contact with a person who has active TB.
Have a chest X-ray
that suggests a TB infection and have not had a complete course of