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    Melanoma/Skin Cancer Health Center

    Medical Reference Related to Melanoma Skin Cancer

    1. Melanoma Treatment (PDQ®): Treatment - Patient Information [NCI] - Changes to This Summary (10 / 09 / 2014)

      The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above.IntroductionAdded Vandergriff et al. as reference 1, Soyer et al. as reference 3, Koster et al. as reference 4, Kamino et al. as reference 5, McCalmont as reference 6, and Kaddu et al. as reference 7.Basal Cell Carcinoma (BCC)Added text about the association of intense, intermittent recreational sun exposure with melanoma and BCC, and chronic occupational sun exposure with squamous cell carcinoma. Also added text about available data regarding regular sunscreen use and skin cancer risk reduction (cited Green et al. [J Epidemiol 1999] as reference 5, Pandeya et al. as reference 6, and Green et al. [Lancet 1999] as reference 7).Added text to state that tanning bed use has also been associated with an increased risk of BCC. Also added text about a study of 376 individuals with BCC and 390 control

    2. Melanoma Treatment (PDQ®): Treatment - Patient Information [NCI] - General Information About Skin Cancer

      Skin cancer is a disease in which malignant (cancer) cells form in the tissues of the skin. The skin is the body’s largest organ. It protects against heat,sunlight,injury,and infection. Skin also helps control body temperature and stores water,fat,and vitamin D. The skin has several layers,but the two main layers are the epidermis (upper or outer layer) and the dermis (lower or inner ...

    3. Melanoma Treatment (PDQ®): Treatment - Patient Information [NCI] - Get More Information From NCI

      Call 1-800-4-CANCERFor more information, U.S. residents may call the National Cancer Institute's (NCI's) Cancer Information Service toll-free at 1-800-4-CANCER (1-800-422-6237) Monday through Friday from 8:00 a.m. to 8:00 p.m., Eastern Time. A trained Cancer Information Specialist is available to answer your questions.Chat online The NCI's LiveHelp® online chat service provides Internet users with the ability to chat online with an Information Specialist. The service is available from 8:00 a.m. to 11:00 p.m. Eastern time, Monday through Friday. Information Specialists can help Internet users find information on NCI Web sites and answer questions about cancer. Write to usFor more information from the NCI, please write to this address:NCI Public Inquiries Office9609 Medical Center Dr. Room 2E532 MSC 9760Bethesda, MD 20892-9760Search the NCI Web siteThe NCI Web site provides online access to information on cancer, clinical trials, and other Web sites and organizations that offer support

    4. Melanoma Treatment (PDQ®): Treatment - Patient Information [NCI] - nci_ncicdr0000258015-nci-header

      This information is produced and provided by the National Cancer Institute (NCI). The information in this topic may have changed since it was written. For the most current information, contact the National Cancer Institute via the Internet web site at http://cancer.gov or call 1-800-4-CANCER.Intraocular (Eye) Melanoma Treatment

    5. Melanoma Treatment (PDQ®): Treatment - Patient Information [NCI] - Treatment Option Overview

      There are different types of treatment for patients with melanoma. Different types of treatment are available for patients with melanoma. Some treatments are standard (the currently used treatment), and some are being tested in clinical trials. A treatment clinical trial is a research study meant to help improve current treatments or obtain information on new treatments for patients with cancer. When clinical trials show that a new treatment is better than the standard treatment, the new treatment may become the standard treatment. Patients may want to think about taking part in a clinical trial. Some clinical trials are open only to patients who have not started treatment.Five types of standard treatment are used:Surgery Surgery to remove the tumor is the primary treatment of all stages of melanoma. The doctor may remove the tumor using the following operations: Wide local excision: Surgery to remove the melanoma and some of the normal tissue around it. Some of the lymph nodes may

    6. Melanoma Treatment (PDQ®): Treatment - Patient Information [NCI] - To Learn More About Melanoma

      For more information from the National Cancer Institute about melanoma, see the following:Melanoma Home PageWhat You Need to Know About™ Melanoma and Other Skin CancersSkin Cancer PreventionSkin Cancer ScreeningSentinel Lymph Node BiopsyDrugs Approved for MelanomaBiological Therapies for CancerUnderstanding Cancer Series: Targeted Therapies (Advances in Targeted Therapies)Targeted Cancer TherapiesFor general cancer information and other resources from the National Cancer Institute, see the following:What You Need to Know About™ CancerUnderstanding Cancer Series: CancerCancer StagingChemotherapy and You: Support for People With CancerRadiation Therapy and You: Support for People With CancerCoping with Cancer: Supportive and Palliative CareQuestions to Ask Your Doctor About CancerCancer LibraryInformation For Survivors/Caregivers/Advocates

    7. Melanoma Treatment (PDQ®): Treatment - Patient Information [NCI] - About This PDQ Summary

      Purpose of This SummaryThis PDQ cancer information summary for health professionals provides comprehensive, peer-reviewed, evidence-based information about skin cancer screening. It is intended as a resource to inform and assist clinicians who care for cancer patients. It does not provide formal guidelines or recommendations for making health care decisions.Reviewers and UpdatesThis summary is reviewed regularly and updated as necessary by the PDQ Screening and Prevention Editorial Board, which is editorially independent of the National Cancer Institute (NCI). The summary reflects an independent review of the literature and does not represent a policy statement of NCI or the National Institutes of Health (NIH). Board members review recently published articles each month to determine whether an article should:be discussed at a meeting,be cited with text, orreplace or update an existing article that is already cited.Changes to the summaries are made through a consensus process in which

    8. Melanoma Treatment (PDQ®): Treatment - Patient Information [NCI] - Cellular and Molecular Classification of Melanoma

      Following is a list of clinicopathologic cellular subtypes of malignant melanoma. These should be considered descriptive terms of historic interest only as they do not have independent prognostic or therapeutic significance. Superficial spreading.Nodular.Lentigo maligna.Acral lentiginous (palmar/plantar and subungual).Miscellaneous unusual types: Mucosal lentiginous (oral and genital).Desmoplastic.Verrucous. Identification of activating mutations in the mitogen-activated protein kinase pathway has led to the definition of molecular subtypes of melanoma and provided potential drug targets.BRAF (V-raf murine sarcoma viral oncogene homolog B1) gene, first reported in 2002, are the most frequent mutation in cutaneous melanoma. Approximately 40% to 60% of malignant melanomas harbor a single nucleotide transversion. The majority have a mutation that results in a substitution from valine to glutamic acid at position 600 BRAF (V600E); less frequent mutations include valine 600 to lysine or

    9. Melanoma Treatment (PDQ®): Treatment - Patient Information [NCI] - Description of the Evidence

      BackgroundIncidence and mortalityThere are three main types of skin cancer:Basal cell carcinoma.Squamous cell carcinoma (together with basal cell carcinoma, this is referred to as nonmelanoma skin cancer).Melanoma.Basal cell carcinoma and squamous cell carcinoma are the most common forms of skin cancer but have substantially better prognoses than the less common, generally more aggressive melanoma.Nonmelanoma skin cancer is the most commonly occurring cancer in the United States. Its incidence appears to be increasing in some [1] but not all [2] areas of the United States. Overall U.S. incidence rates have likely been increasing for a number of years.[3] At least some of this increase may be attributable to increasing skin cancer awareness and resulting increasing investigation and biopsy of skin lesions. A precise estimate of the total number and incidence rate of nonmelanoma skin cancer is not possible, because reporting to cancer registries is not required. However, based on

    10. Melanoma Treatment (PDQ®): Treatment - Patient Information [NCI] - Recurrent Metastatic Squamous Neck Cancer with Occult Primary

      Recurrent metastatic squamous neck cancer with occult primary is cancer that has recurred (come back) after it has been treated. The cancer may come back in the neck or other parts of the body.

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