There are different types of treatments for patients with intraocular melanoma. Some treatments are standard (the currently used treatment), and some are being tested in clinical trials. Before starting treatment,patients may want to think about taking pa
Get more information on melanoma treatment. How to contact the National Cancer Institute (NCI) via phone (1-800-4-Cancer), online, or mail. Plus, details on how to search the NCI web site, and how to order NCI publications.
The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above.Basal Cell CarcinomaAdded text to state that several sets of clinical diagnostic criteria for basal cell nevus syndrome (BCNS) are in use (cited Evans et al. and Veenstra-Knol et al. as references 66 and 68, respectively). Also added text to state that although each set of criteria has advantages and disadvantages, none of the sets have a clearly superior balance of sensitivity and specificity for identifying mutation carriers; PTCH1 mutations are found in 60% to 85% of patients who meet clinical criteria (cited Klein et al. as reference 69). Added Table 1, Comparison of Diagnostic Criteria for BCNS.Added text about a 9p22.3 microdeletion syndrome that includes the PTCH1 locus that has been described in ten children, all of whom had facial features of BCNS (cited Muller et al. as reference
The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above. Editorial changes were made to this summary.
PDQ IS A COMPREHENSIVE CANCER DATABASE AVAILABLE ON NCI'S WEB SITE. PDQ is the National Cancer Institute's (NCI's) comprehensive cancer information database. Most of the information contained in PDQ is available online at NCI's Web site. PDQ is provided as a service of the NCI. The NCI is part of the National Institutes of Health,the federal government's focal point for biomedical research. .
The natural history of small choroidal melanoma remains poorly understood. Small,pigmented choroidal lesions cannot always be differentiated reliably on examination. Growth is a presumed indicator of malignant potential.[ 1 ] Although patients diagnosed with small choroidal tumors were not eligible for participation in the Collaborative Ocular Melanoma Study,these patients were offered ...
The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above.Editorial changes were made to this summary.
Incidence and MortalityMelanoma of the uveal tract (iris, ciliary body, and choroid), though rare, is the most common primary intraocular malignancy in adults. The mean age-adjusted incidence of uveal melanoma in the United States is approximately 4.3 new cases per million population, with no clear variation by latitude. Males have a higher incidence than females (4.9 vs. 3.7 per million). The age-adjusted incidence of this cancer has remained stable since at least the early 1970s.[1,2] U.S. incidence rates are low compared with the rates of other reporting countries, which vary from about 5.3 to 10.9 cases per million. Some of the variation may be the result of differences in inclusion criteria and methods of calculation.Uveal melanoma is diagnosed mostly at older ages, with a progressively rising, age-specific, incidence rate that peaks near the age of 70 years. Host susceptibility factors associated with the development of this cancer include:[2,3,4]Caucasian race.Light