Stage II melanoma is defined by the American Joint Committee on Cancer's TNM classification system:T2b, N0, M0T3a, N0, M0T3b, N0, M0T4a, N0, M0T4b, N0, M0Standard Treatment Options for Patients With Stage II MelanomaCurrent evidence suggests that for melanomas with a thickness between 2 mm and 4 mm, the surgical margins need to be 2 cm or less. The Intergroup Melanoma Surgical Trial compared 2-cm margins versus 4-cm margins for patients with 1-mm thick melanomas to 4-mm thick melanomas. With a median follow-up of more than 10 years, no significant difference was observed between the two groups in terms of local recurrence or survival. The reduction in margins from 4 cm to 2 cm was associated with a statistically significant reduction in the need for skin grafting (46% to11%; P < .001) and a reduction in the length of the hospital stay. Depending on the location of the melanoma, most patients can now have this surgery performed on an outpatient basis. A study conducted in
A link to a list of current clinical trials is included for each treatment section. For some types or stages of cancer, there may not be any trials listed. Check with your doctor for clinical trials that are not listed here but may be right for you.Untreated Metastatic Squamous Neck Cancer with Occult PrimaryTreatment of untreated metastatic squamous neck cancer with occult primary may include the following:Radiation therapy.Surgery.Radiation therapy followed by surgery.A clinical trial of chemotherapy followed by radiation therapy.A clinical trial of chemotherapy given at the same time as hyperfractionated radiation therapy.Clinical trials of new treatments.Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with untreated metastatic squamous neck cancer with occult primary. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug.
There are different types of treatment for patients with metastatic squamous neck cancer with occult primary. Different types of treatment are available for patients with metastatic squamous neck cancer with occult primary. Some treatments are standard (the currently used treatment), and some are being tested in clinical trials. A treatment clinical trial is a research study meant to help improve current treatments or obtain information on new treatments for patients with cancer. When clinical trials show that a new treatment is better than the standard treatment, the new treatment may become the standard treatment. Patients may want to think about taking part in a clinical trial. Some clinical trials are open only to patients who have not started treatment.Two types of standard treatment are used:Surgery Surgery may include neck dissection. There are different types of neck dissection, based on the amount of tissue that is removed. Radical neck dissection: Surgery to remove tissues
Radiation therapy uses high doses of radiation to destroy or shrink advanced or metastatic melanoma with little harm to nearby healthy tissue. Radiation damages the genetic material of cancer cells, stopping their growth. Treatment is usually done several times a week for up to 6 weeks. ...
Nonmelanoma skin cancer may appear as a change in the skin, such as a growth, an irritation or sore that does not heal, or a change in a wart or mole. Basal cell carcinoma usually affects the head, neck, back, chest, or shoulders. The nose is the most com
The primary risk factor for developing melanoma is excessive exposure to ultraviolet (UV) radiation from the sun. Some experts believe that 65% or more of melanoma is caused by exposure to the sun, especially during childhood.