Stage III Melanoma
Treatment Options for Patients With Unresectable Stage III Disease
Treatment options for patients with unresectable disease include the following:
- Patients with unresectable disease are entered into trials recruiting stage IV patients. See stage IV section for clinical trial results and treatment options.
Treatment Options Under Clinical Evaluation for Patients With Stage III Melanoma
Treatment options under clinical evaluation for patients with stage III melanoma include the following:
- EORTC-18071 (NCT00636168), in collaboration with centers in the United States, is conducting a phase III randomized trial of ipilimumab versus placebo in patients with high-risk stage III melanoma who have undergone an adequate surgical resection. The Eastern Cooperative Oncology Group is preparing to launch a U.S. adjuvant trial (E4697) of ipilimumab in stage III and stage IV patients who have resectable disease.
- For patients with in-transit and/or satellite lesions (stage IIIC) of the extremities, hyperthermic isolated limb perfusion (ILP) with melphalan (L-PAM) with or without tumor necrosis factor-alpha (TNF-alpha) has resulted in high tumor response rates and palliative benefit. Results from a multicenter, randomized, phase II study showed no benefit from adding interferon-gamma to a regimen of L-PAM plus TNF-alpha. Clinical trials such as the ACOSOG-Z0020 and MSKCC-99047 trials, for example, have evaluated ILP using L-PAM in combination with TNF or other chemotherapeutic agents.
- Intratumoral injections of replication-competent oncolytic viruses of unresectable lesions are being tested in national clinical trials.
Current Clinical Trials
Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with stage III melanoma. The list of clinical trials can be further narrowed by location, drug, intervention, and other criteria.
General information about clinical trials is also available from the NCI Web site.
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