Find Information About:

Drugs & Supplements

Get information and reviews on prescription drugs, over-the-counter medications, vitamins, and supplements. Search by name or medical condition.

Pill Identifier

Pill Identifier

Having trouble identifying your pills?

Enter the shape, color, or imprint of your prescription or OTC drug. Our pill identification tool will display pictures that you can compare to your pill.

Get Started

My Medicine

Save your medicine, check interactions, sign up for FDA alerts, create family profiles and more.

Get Started

WebMD Health Experts and Community

Talk to health experts and other people like you in WebMD's Communities. It's a safe forum where you can create or participate in support groups and discussions about health topics that interest you.

  • Second Opinion

    Second Opinion

    Read expert perspectives on popular health topics.

  • Community


    Connect with people like you, and get expert guidance on living a healthy life.

Got a health question? Get answers provided by leading organizations, doctors, and experts.

Get Answers

Sign up to receive WebMD's award-winning content delivered to your inbox.

Sign Up

Multiple Sclerosis Health Center

Font Size

Multiple Sclerosis: Medicines for Muscle Stiffness and Tremors - Topic Overview


Several medicines may be used to treat muscle stiffness (spasticity) caused by multiple sclerosis (MS).

  • Baclofen (Lioresal) is the drug of choice for spasticity. It is available in tablets or by delivery through a pump implanted in the lower spinal area. Pump delivery is effective for those with severe spasticity.
  • Tizanidine (Zanaflex) is a drug similar to baclofen. It is available in tablet form.
  • Dantrolene (Dantrium) is also effective. But it may cause muscle weakness, which limits the number of people who can use it. Other side effects may include nausea, vomiting, lack of hunger (anorexia), and, with high dosages or prolonged use, liver damage.
  • Gabapentin (Neurontin) may help relieve pain as well as spasticity. It is usually very well tolerated and causes few side effects.
  • Diazepam (Valium) and clonazepam (Klonopin) relieve both spasticity and anxiety but may cause side effects such as dizziness, drowsiness, and confusion.
  • Injection of botulinum toxin (Botox) may provide relief in some cases.1

Often a combination of these medicines given in small doses is better tolerated and more effective than a larger dose of a single medicine.

Recommended Related to Multiple Sclerosis

Work & Multiple Sclerosis

How to handle workplace issues when you have multiple sclerosis. Elissa Levy, a 37-year-old with secondary progressive multiple sclerosis (MS), is living proof of the unpredictability of this progressive neurological disease that affects the central nervous system. Soon after being diagnosed in January 2002, her physical status plummeted quickly. The former fitness buff who regularly skied and jogged describes the overwhelming MS-induced fatigue that plagued her almost daily. "Sometimes my eyes...

Read the Work & Multiple Sclerosis article > >

Some forms of natural or man-made substances related to marijuana, called cannabinoids, may help relieve spasticity.


Carbamazepine (Tegretol), which is a seizure medicine, benzodiazepines such as diazepam (Valium) and clonazepam (Klonopin), and beta-blockers, especially propranolol (Inderal), may have some benefit in treating tremors caused by MS.

Severe tremors are very hard to treat. If they do not respond to medicine, surgery may be needed.

The U.S. Food and Drug Administration (FDA) has issued a warning on seizure medicines and the risk of suicide and suicidal thoughts. The FDA does not recommend that people stop using these medicines. Instead, people who take seizure medicine should be watched closely for warning signs of suicide. People who take seizure medicine and who are worried about this side effect should talk to a doctor.

    WebMD Medical Reference from Healthwise

    Last Updated: May 22, 2014
    This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.
    Next Article:

    Multiple Sclerosis: Medicines for Muscle Stiffness and Tremors Topics

    Today on WebMD

    nerve damage
    Learn how this disease affects the nervous system.
    woman applying lotion
    Ideas on how to boost your mood and self-esteem.
    woman pondering
    Get personalized treatment options.
    man with hand over eye
    Be on the lookout for these symptoms.
    brain scan
    worried woman
    neural fiber
    white blood cells
    sunlight in hands
    marijuana plant
    muscle spasm