Baclofen (Lioresal) is the drug of choice for
spasticity. It is available in tablets or by delivery through a pump implanted
in the lower spinal area. Pump delivery is effective for those with severe
Tizanidine (Zanaflex) is a drug similar to baclofen. It
is available in tablet form.
Dantrolene (Dantrium) is also
effective. But it may cause muscle weakness, which limits the number of
people who can use it. Other side effects may include nausea, vomiting, lack of
hunger (anorexia), and, with high dosages or prolonged use, liver
Gabapentin (Neurontin) may help relieve pain as well as
spasticity. It is usually very well tolerated and causes few side
Diazepam (Valium) and clonazepam (Klonopin) relieve both
spasticity and anxiety but may cause side effects such as dizziness,
drowsiness, and confusion.
Injection of botulinum toxin
(Botox) may provide relief in some cases.1
Often a combination of these medicines given in small
doses is better tolerated and more effective than a larger dose of a single
When you have MS, your emotions are in play. While having MS raises your chances of having depression, knowing that fact -- and being aware -- can help you try to prevent it and get treatment. Protect yourself with healthy habits.
Get moving. When it comes to MS treatment, exercise is a two-for-one. Being active improves MS symptoms -- like fatigue and bladder problems -- and improves your mood, says Rosalind Kalb, PhD, vice president of clinical care at the National Multiple Sclerosis Society...
Some people try alternative therapy. One study found
that 97% of people who used marijuana reported improvement in spasticity and
Carbamazepine (Tegretol), which is a seizure
medicine, benzodiazepines such as diazepam (Valium) and clonazepam
(Klonopin), and beta-blockers, especially propranolol (Inderal), may have some
benefit in treating
tremors caused by MS.
Severe tremors are
very hard to treat. If they do not respond to medicine, surgery may be
The U.S. Food and Drug Administration (FDA) has issued a
warning on seizure medicines and the risk of suicide and suicidal thoughts. The
FDA does not recommend that people stop using these medicines. Instead, people
who take seizure medicine should be watched closely for
warning signs of suicide. People who take seizure
medicine and who are worried about this side effect should talk to a