Paget's disease is a chronic disease that affects how
the body breaks down and rebuilds bone tissue. Paget's disease can be active or
inactive, depending on whether the bone formation process goes too quickly or
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In inactive Paget's disease,
bone tissue is being broken down and rebuilt at a
normal speed. This most often occurs when you are using medicine to slow the
bone growth. The inactive state may continue even after you stop taking
medicine. This is called
Active Paget's disease
Active Paget's disease has three stages. They are:
Hot (lytic) stage. This stage occurs early in the
disease process, when bone tissue is being quickly broken down. Bones are often
more painful during this stage.
Mixed stage. This stage occurs
later in the disease process, when bone tissue is being quickly broken down and
Cold (rebuilding) stage. This stage occurs later
in the disease, when bone tissue is being quickly rebuilt.
Bone pain may occur in any of the stages.
In this article
This information is produced and provided by the National
Institute (NCI). The information in this topic may have changed since it was written. For the most current information, contact the National
Institute via the Internet web site at http://
.gov or call 1-800-4-CANCER.
WebMD Medical Reference from Healthwise
August 30, 2013
This information is not intended to replace the advice of a doctor.
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