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Active and Inactive Paget's Disease - Topic Overview

Paget's disease is a chronic disease that affects how the body breaks down and rebuilds bone tissue. Paget's disease can be active or inactive, depending on whether the bone formation process goes too quickly or normally.

Inactive Paget's disease

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In inactive Paget's disease, bone tissue is being broken down and rebuilt at a normal speed. This most often occurs when you are using medicine to slow the bone growth. The inactive state may continue even after you stop taking medicine. This is called remission.

Active Paget's disease

Active Paget's disease has three stages. They are:

  • Hot (lytic) stage. This stage occurs early in the disease process, when bone tissue is being quickly broken down. Bones are often more painful during this stage.
  • Mixed stage. This stage occurs later in the disease process, when bone tissue is being quickly broken down and quickly rebuilt.
  • Cold (rebuilding) stage. This stage occurs later in the disease, when bone tissue is being quickly rebuilt.

Bone pain may occur in any of the stages.

    This information is produced and provided by the National Cancer Institute (NCI). The information in this topic may have changed since it was written. For the most current information, contact the National Cancer Institute via the Internet web site at http:// cancer .gov or call 1-800-4-CANCER.

    WebMD Medical Reference from Healthwise

    Last Updated: August 30, 2013
    This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.
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