Illustration Of Ovarian Cancer
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What Is Ovarian Cancer?

Current research suggests this cancer begins in the fallopian tubes and moves to the ovaries, the twin organs that produce a woman's eggs and the main source of  the female hormones estrogen and progesterone. Treatments for ovarian cancer have become more effective in recent years, with the best results seen when the disease is found early.

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Woman With Abdominal Pain
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Ovarian Cancer Symptoms

Symptoms include:

  • Bloating or pressure in the belly
  • Pain in the abdomen or pelvis
  • Feeling full too quickly during meals
  • Urinating more frequently

These symptoms can be caused by many conditions that are not cancer. If they occur persistently for more than a few weeks, report them to your health care professional.

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Woman Looking At Genealogical Tree
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Risk Factor: Family History

A woman's odds of developing ovarian cancer are higher if a close relative has had cancer of the ovaries, breast, or colon. Researchers believe that inherited genetic changes account for 10% of ovarian cancers. This includes the BRCA1 and BRCA2 gene mutations, which are linked to breast cancer.  Women with a strong family history should talk with a doctor to see whether closer medical follow-up could be helpful.

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Three Generations Of Women
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Risk Factor: Age

The  strongest risk factor for ovarian cancer is age. It's most likely to develop after a woman goes through menopause. Using postmenopausal hormone therapy may increase the risk. The link seems strongest in women who take estrogen without progesterone for at least 5 to 10 years. Doctors are not certain whether taking a combination of estrogen and progesterone boosts the risk as well.

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Two Obese Women
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Risk Factor: Obesity

Obese women have a higher risk of getting ovarian cancer than other women. And the death rates for ovarian cancer are higher for obese women too, compared with non-obese women. The heaviest women appear to have the greatest risk.

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Blood Sample On Glass Slide
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Ovarian Cancer Screening Tests

There is no easy or reliable way to test for ovarian cancer if a woman has no symptoms. However, there are two ways to screen for ovarian cancer during a routine gynecologic exam. One is a blood test for elevated levels of a protein called CA-125. The other is an ultrasound of the ovaries. Unfortunately, neither technique has been shown to save lives when used in women of average risk. For this reason, screening is only recommended for women with strong risk factors.

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Ovarian CT Scan
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Diagnosing Ovarian Cancer

Imaging tests, such as ultrasound or CT scans (seen here), can help reveal an ovarian mass. But these scans can't determine whether the abnormality is cancer. If cancer is suspected, the next step is usually surgery to remove suspicious tissues. A sample is then sent to the lab for further examination. This is called a biopsy. 

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Close Up Illustration Of Ovarian Cancer
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Stages of Ovarian Cancer

The initial surgery for ovarian cancer also helps determine how far the cancer has spread, described by the following stages:

Stage I: Confined to one or both ovaries
Stage II: Spread to the uterus or other nearby organs
Stage III: Spread to the lymph nodes or abdominal lining
Stage IV: Spread to distant organs, such as the lungs or liver

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Cancer Cells In Ovary
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Types of Ovarian Cancer

The vast majority of ovarian cancers are epithelial ovarian carcinomas. These are malignant tumors that form from cells on the surface of the ovary. Some epithelial tumors are not clearly cancerous. These are known as tumors of low malignant potential (LMP). LMP tumors grow more slowly and are less dangerous than other forms of ovarian cancer.

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Woman Swimming Laps In Pool
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Ovarian Cancer Survival Rates

Ovarian cancer can be a frightening diagnosis, with five-year relative survival rates that range from 90% to 17% for epithelial ovarian cancer, depending on the stage when the cancer was found. For LMP tumors, the five-year relative survival rates range from 97% to 89%.

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Woman Being Wheeled In To Surgery
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Ovarian Cancer Surgery

Surgery is used to diagnose ovarian cancer and determine its stage, but it is also the first phase of treatment. The goal is to remove as much of the cancer as possible. This may include a single ovary and nearby tissue in stage I. In more advanced stages, it may be necessary to remove both ovaries, along with the uterus and surrounding tissues.

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Chemotherapy Drug Treatment
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Chemotherapy

In all stages of ovarian cancer, chemotherapy is usually given after surgery. This phase of treatment uses drugs to target and kill any remaining cancer in the body. The drugs may be given by mouth, through an IV, or directly into the belly (intraperitoneal chemotherapy). Women with LMP tumors usually don't need chemo unless the tumors grow back after surgery.

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Ovarian Cancer Tumor
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Targeted Therapies

Researchers are working on therapies that target the way ovarian cancer grows. A process called angiogenesis involves the formation of new blood vessels to feed tumors. A drug called Avastin blocks this process, causing tumors to shrink or stop growing (seen in the illustration here). 

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Woman Chatting With Doctor After Treatment
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After Treatment: Early Menopause

When women have both ovaries removed, they can no longer produce their own estrogen. This triggers menopause, no matter how young the patient. The drop in hormone levels can also raise the risk for certain medical conditions, including osteoporosis. It's vital that women have regular follow-up care after being treated for ovarian cancer.

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Ovarian Cancer Survivor
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After Treatment: Moving On

Women may find that it takes a long time for their energy to return after treatments end. Fatigue is a very common problem after treatment for cancer. Beginning a gentle exercise program is one of the most effective ways to restore energy and improve emotional well-being. Check with your health care team to determine which activities are right for you.

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Woman Holding Newborn Baby
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Risk Reducer: Pregnancy

Women who have biological children are less likely to get ovarian cancer than women who have never given birth. The risk appears to decrease with every pregnancy, and breastfeeding may offer added protection.

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Package Of Birth Control Pills
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Risk Reducer: 'The Pill'

Ovarian cancer is also less common in women who have taken birth control pills. Women who have used the pill for at least five years have about half the risk of women who never took the pill. Like pregnancy, birth control pills prevent ovulation. Some researchers think ovulating less often may protect against ovarian cancer.

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Illustration Of Tubal Litigation
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Risk Reducer: Tubal Ligation

Getting your tubes tied, formally known as tubal ligation, may offer some protection against ovarian cancer. The same goes for having a hysterectomy -- removing the uterus.

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Surgeon With Scalpel
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Risk Reducer: Removing the Ovaries

For women with genetic mutations that put them at high risk for ovarian cancer, removing the ovaries is an option. This can also be considered in women over 40 getting a hysterectomy.

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Low Fat Salmon With Salad
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Risk Reducer: Low-Fat Diet

While there is no definitive diet to prevent ovarian cancer, there is evidence that what you eat can make a difference. In one recent study, women who stuck to a low-fat diet for at least four years were less likely to develop ovarian cancer. Some researchers report the cancer is also less common in women who eat a lot of vegetables, but more studies are needed.

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Sources | Medically Reviewed on 05/19/2016 Reviewed by Laura J. Martin, MD on May 19, 2016

IMAGES PROVIDED BY:

1)         3D4Medical.com
2)         Jupiterimages
3)         Tom Merton/OJO Images
4)         Eric Audras/PhotoAlto
5)         Dirk Enters/Imagebroker.net
6)         Adam Gault/OJO Images
7)         Du Cane Medical Imaging Ltd. / Photo Researchers, Inc.
8)         Kevin A. Somerville/Phototake
9)         Professors Pietro M. Motta & Sayoko Makabe / Photo Researchers, Inc
10)       Digital Vision
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13)       Phototake
14)       Digital Vision
15)       Tom Merton/OJO Images
16)       Christian Baitg/Photographer's Choice
17)       Ian Hooton/Science Photo Library
18)       Brain Evans/Photo Researchers Inc
19)       LWA-Stephen Welstead/Flirt
20)       Joff Lee/Fresh Food Images

REFERENCES:

American Cancer Society web site.
National Cancer Institute web site.
North American Menopause Society web site.

Reviewed by Laura J. Martin, MD on May 19, 2016

This tool does not provide medical advice. See additional information.

THIS TOOL DOES NOT PROVIDE MEDICAL ADVICE. It is intended for general informational purposes only and does not address individual circumstances. It is not a substitute for professional medical advice, diagnosis or treatment and should not be relied on to make decisions about your health. Never ignore professional medical advice in seeking treatment because of something you have read on the WebMD Site. If you think you may have a medical emergency, immediately call your doctor or dial 911.