Neurofibromatoses are genetic disorders of the nervous system. Mainly, these disorders affect the growth and development of nerve cell tissue. The disorders are known as neurofibromatosis type 1 (NF1) and neurofibromatosis type 2 (NF2). NF1 is the more common type of neurofibromatosis. Schwannomatosis has recently been identified as a third and more rare type of neurofibromatosis, but little is known about it.
NF1, also called von Recklinghausen NF or peripheral NF, is characterized by multiple café au lait spots (patches of tan or light brown skin) and neurofibromas (soft, fleshy growths) on or under the skin. Enlargement and deformation of bones and curvature of the spine (scoliosis) may also occur. Occasionally, tumors may develop in the brain, on cranial nerves, or on the spinal cord. About 50% to 75% of people with NF1 also have learning disabilities.
By Ellen Strum
Treat your feet right, and they’ll keep you “outstanding.”
After a day on your feet, your feet likely hate you—and you hate them, too. "If your feet aren't healthy, it affects how you function and live your life," says Dr. Helena Reid, D.P.M., of Moline, Ill., a spokeswoman for the American Podiatric Medical Association. Plus, she adds, foot pain can cause you to walk abnormally, throwing off your alignment and putting unnatural pressure on your knees, hips, and lower...
NF2, also called bilateral acoustic NF (BAN), is much less common than NF1 and is characterized by multiple tumors on the cranial and spinal nerves. Tumors that affect both of the auditory nerves and hearing loss beginning in the teens or early twenties are generally the first symptom of NF2.
What Causes Neurofibromatosis?
Neurofibromatosis is often inherited (passed on by family members through our genes), but about 50% of people newly diagnosed with the disorder have no family history of the condition, which can arise spontaneously through a mutation (change) in the genes. Once this change has taken place, the mutant gene can be passed on to future generations.