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Pain Management Health Center

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Tylenol Safety Debated -- Again

Recommended Dose Safe, but Overdose Danger Debatable

Acetaminophen Misconceptions Abound

Lee's article is one of two point/counterpoint editorials in Hepatology. The companion piece is by Barry H. Rumack, emeritus director of the Rocky Mountain Poison and Drug Center and professor of pediatrics at the University of Colorado School of Medicine.

Rumack says Lee is working backward, trying to find out why people are dying of liver failure. Sure, he's finding evidence that sick people take Tylenol, but that's what sick people tend to do. Studies that look at what happens when people take acetaminophen, he says, don't raise red flags.

"I do not believe acetaminophen, at therapeutic doses, taken according to directions, produces toxicity," Rumack tells WebMD. "The few reports that suggest that don't prove anything, because the blood levels they are based on don't satisfy any scientific basis. All prospective studies show absolutely no toxicity."

One common misconception about acetaminophen, Lee says, is that it shouldn't be used by people who drink alcohol.

"I just don't believe that the casual alcohol drinker is at risk at therapeutic doses," Rumack says. "There is no data that acetaminophen is dangerous for a hangover."

Rumack argues that the dose of acetaminophen needed for liver toxicity is nearly 16 grams -- 32 extra-strength acetaminophen tablets. In chronic alcohol users, the toxic dose is lower -- 13 grams, or 26 extra-strength pills.

"Chronic severe alcoholics taking an overdose of acetaminophen are at greater risk than nonchronic alcoholics," Rumack says. "The person who has three drinks a day -- the one the Tylenol label warns to call a doctor -- is not at changed risk. If that person takes an overdose, they are at the same risk as anyone else. But a chronic alcoholic taking an overdose is clearly at higher risk."

More Study Needed

The fact that this argument continues shows that more research is needed, Anania says.

"For all we know, the increase in acetaminophen-related liver toxicity that Dr. Lee is seeing may be that fatty liver may lead to obese people not being able to deal with the drug," he says. "But we have not dealt with that yet. There is a lot of information lacking on the part of doctors, the FDA, and the industry."

And in addition to more research, Anania has three words of advice for both patients and doctors.

"Education, education, education. That's what we need," he says. "This is a debate that has been going on for a long time. I don't think restricting Tylenol is the answer. There is a need for education and better labeling. And education of physicians would help, too."

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