Tylenol Safety Debated -- Again
Recommended Dose Safe, but Overdose Danger Debatable
WebMD News Archive
Acetaminophen Misconceptions Abound
Lee's article is one of two point/counterpoint editorials in
Hepatology. The companion piece is by Barry H. Rumack, emeritus director
of the Rocky Mountain Poison and Drug Center and professor of pediatrics at the
University of Colorado School of Medicine.
Rumack says Lee is working backward, trying to find out why
people are dying of liver failure. Sure, he's finding evidence that sick people
take Tylenol, but that's what sick people tend to do. Studies that look at what
happens when people take acetaminophen, he says, don't raise red flags.
"I do not believe acetaminophen, at therapeutic doses,
taken according to directions, produces toxicity," Rumack tells WebMD.
"The few reports that suggest that don't prove anything, because the blood
levels they are based on don't satisfy any scientific basis. All prospective
studies show absolutely no toxicity."
One common misconception about acetaminophen, Lee says, is that
it shouldn't be used by people who drink alcohol.
"I just don't believe that the casual alcohol drinker is at
risk at therapeutic doses," Rumack says. "There is no data that
acetaminophen is dangerous for a hangover."
Rumack argues that the dose of acetaminophen needed for liver
toxicity is nearly 16 grams -- 32 extra-strength acetaminophen tablets. In
chronic alcohol users, the toxic dose is lower -- 13 grams, or 26
"Chronic severe alcoholics taking an overdose of
acetaminophen are at greater risk than nonchronic alcoholics," Rumack says.
"The person who has three drinks a day -- the one the Tylenol label warns
to call a doctor -- is not at changed risk. If that person takes an overdose,
they are at the same risk as anyone else. But a chronic alcoholic taking an
overdose is clearly at higher risk."
More Study Needed
The fact that this argument continues shows that more research
is needed, Anania says.
"For all we know, the increase in
acetaminophen-related liver toxicity that Dr. Lee is seeing may be that fatty
liver may lead to obese people not being able to deal with the drug," he
says. "But we have not dealt with that yet. There is a lot of information
lacking on the part of doctors, the FDA, and the industry."
And in addition to more research, Anania has three words of
advice for both patients and doctors.
"Education, education, education. That's what we need,"
he says. "This is a debate that has been going on for a long time. I don't
think restricting Tylenol is the answer. There is a need for education and
better labeling. And education of physicians would help, too."