Placebo Effect May Help Treat Pain
Pain Study Traces Placebo Effect to the Spinal Cord
Oct. 15, 2009 -- The "placebo effect" may help treat pain, German
researchers report in Science.
When someone experiences the placebo effect, they're responding to an
inactive drug or sham procedure that isn't supposed to affect their
The placebo effect is often called psychological -- the brain believes it's
getting real help and rallies, even though the placebo itself doesn't contain
Now, German researchers report that when it comes to pain, the placebo
effect affects activity in part of the spinal cord called the dorsal horn.
Falk Eippert and colleagues at Germany's University Medical Center
Hamburg-Eppendorf studied 15 healthy young men.
First, the researchers applied heat to the men's arms in order to gauge
their pain threshold.
Next, they treated the men's arms with two identical, inactive creams. But
the researchers told the men that one of the creams was "an extremely effective
painkiller" and that the other cream was a "control cream."
Finally, the researchers applied heat to the treated areas of the arms to
stimulate the sense of pain.
When the men's arms were treated with the fake painkiller cream before being
subjected to heat, they reported less pain than when their arms were treated
with the control cream. In short, they were experiencing the placebo effect,
just as the researchers had planned.
MRI scans taken during the tests showed less activity in the dorsal horn of
the men's spinal cords, which is involved in sensory perception, when
their arms had been treated with the fake painkiller cream.
Exactly how that happened isn't clear. The study doesn't explain the
mind-body connection between the men's beliefs about the creams and how they
responded to the pain from the heat.
But the findings may open up "new avenues" for assessing the efficacy and
action of new pain treatments, Eippert and colleagues write.