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Pain Management Health Center

Many Unaware of OTC Pain Relievers' Ingredients, Risks

Poll Shows Many Americans Don’t Know the Active Ingredients, Side Effects of Popular Pain Medicines
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WebMD Health News
Reviewed by Laura J. Martin, MD

May 2, 2011 -- Many Americans may be unaware of the active ingredients and potential side effects of popular over-the-counter pain relievers, according to a new study.

Tylenol contains acetaminophen, Bayer contains aspirin, Advil and Motrin contain ibuprofen, and Aleve contains naproxen sodium. But many people know little about the ingredients in their pain relievers, the study suggests.

This is alarming, says Michael Wolf, PhD, MPH, a study researcher and an associate professor of medicine at Northwestern University’s Feinberg School of Medicine.

Acetaminophen and the Liver

Acetaminophen, the ingredient in Tylenol, is found in more than 600 over-the-counter and prescription medications.

But ignorance about which medications contain acetaminophen may be why acetaminophen overdose has become the leading cause of acute liver failure in the United States, according to the study, which was financed by Tylenol’s manufacturer, McNeil Consumer Healthcare.

People Aren’t Aware of Ingredients in Pain Drugs

The researchers say in the study that of the 45 adults in Atlanta and Chicago who were questioned:

  • 31% knew that Tylenol contains acetaminophen.
  • 75% knew Bayer contains aspirin.
  • 47% knew Motrin contains ibuprofen.
  • 19% knew Aleve’s active ingredient is naproxen sodium.
  • 19% knew Advil contains ibuprofen.

Because acetaminophen is sold over the counter, many people consider it safe, not realizing that taking too much of the drug can be dangerous and lead to liver damage.

That’s one reason why researchers say a universal icon for acetaminophen should be developed that would appear on all medicine labels containing the ingredient.

“It’s incredibly alarming,” says Wolf, who has worked as a paid consultant for McNeil Consumer Healthcare. “People may unintentionally misuse these medicines to a point where they cause severe liver damage.”

He says it’s easy “to exceed the safe limit if people don’t realize how much acetaminophen they are taking” and because Tylenol and other products with acetaminophen are sold over the counter, no doctors or pharmacies are monitoring how much people are taking.

Jennifer King, MPH, also of the Feinberg School of Medicine and study co-author, says many people do not realize they may be taking acetaminophen simultaneously in multiple medications.

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