Prostate Cancer Health Center
Advanced Prostate Cancer: Frequently Asked Questions
If you just learned that you or a loved one has advanced prostate cancer, you may have many questions and concerns. By taking the time to research your condition, you've taken a good first step. Here are answers to the most common questions. After looking over these answers, click on other articles in this guide to find in-depth information about treatments, side effects, and other issues that affect you and your family.
What is advanced prostate cancer?
Prostate cancer is defined as 'advanced' when it spreads outside the prostate gland. It may spread to nearby tissues, lymph nodes, bones, or other parts of the body. It is also called metastatic prostate cancer.
Can advanced prostate cancer be cured?
Currently, no cure exists for advanced prostate cancer. Men can benefit, however, in several ways. Some treatments slow the growth of the cancer. Others reduce symptoms caused by the disease. Until recently, no therapy was offered to prolong life. However, the recently approved chemotherapy drug Taxotere, when taken with the steroid prednisone, has been proven to extend survival by several months in those patients in whom it works. Taxotere is approved only for men with cancer that no longer responds to hormone therapy (called hormone refractory prostate cancer).
When Taxotere stops working, a new chemotherapy drug called Jevtana can also extend survival in those that respond to it.
In addition, Provenge, a "vaccine" for the treatment of advanced prostate cancer, does appear to extend survival -- by months for most patients, by years for some. Provenge isn't your everyday vaccine. It's an immune therapy created by harvesting immune cells from a patient, genetically engineering them to fight prostate cancer, and then infusing them back into the patient. It's approved only for treatment of patients with few or no symptoms who have prostate cancer that has spread outside the prostate and no longer responds to hormone therapy.
What are the side effects of treatment?
Most doctors use hormone therapy to control the spread of advanced prostate cancer. The most frequent side effects caused by hormone therapy include reduced sex drive, impotence, infertility, and osteoporosis (weakened bones). Erectile dysfunction and infertility occur in most men who undergo hormone therapy. The risk and extent of bone loss depends largely on how long a man receives hormone therapy. In many cases, doctors can recommend ways to combat these side effects.
When people no longer respond to hormone therapy, doctors may try a chemotherapy drug called Taxotere. Possible side effects of Taxotere include nausea, hair loss, and bone marrow suppression (the decline or halt of blood cell formation). Patients may also develop fluid retention and pain, tingling, or numbness in the fingers or toes. Jevtana has similar side effects to Taxotere.
Though new, thus far Provenge has been remarkably safe. However, clinical trials suggested the treatment might be linked to a slightly increased risk of stroke. Nearly all patients suffer some mild to moderate side effects such as chills, fatigue, fever, back pain, nausea, joint ache, and headache.
It's important for everyone with advanced prostate cancer to discuss their concerns with their doctor before beginning treatment.
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