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Research Into Eczema and Allergies

The eczema-allergy story still isn't fully understood. At one time health experts thought that all types of eczema were caused by allergies. Now we know that the connection is more complicated. Researchers continue to uncover new insights about the causes of eczema that may lead to better treatments. Some recent areas of study include:

Genetic factors. Researchers have found that some people with eczema have a genetic defect that causes a lack of filaggrin in the skin. Filaggrin is a type of protein that helps form the protective outer layer of our skin. This skin barrier protects the body from germs and other foreign substances. A lack of filaggrin dries out and weakens the skin barrier. This makes skin vulnerable to irritants such as soaps and detergents. A weak skin barrier also makes it easier for allergens, such as pollen, to enter the body. Scientists believe that this exposure may cause the sensitivity to allergens and even certain foods.

Allergen sensitivity. Some research has found that people with eczema may have a defect in their skin barrier. When allergens enter the skin, they prompt the body to make chemicals that lead to inflammation. Research also points to a problem with a type of white blood cell that releases chemicals that regulate allergic reactions in the body. This may help explain why people with eczema have outbreaks when exposed to allergens.

An overproduction of antibodies. Immunoglobulin E (IgE) is a type of antibody that plays a role in the body's allergic response. People with eczema have higher than normal levels of IgE. Researchers are working to understand why people with eczema produce too much IgE and what role this may play in the disease.

Skin barrier defects. A barrier defect is a term that refers to small gaps in the skin. These gaps allow the skin to lose moisture too quickly. They may also provide a way for germs to enter the body.

How to Avoid Allergy Triggers to Prevent Eczema Flare-Ups

To manage eczema, you need to moisturize daily and use recommended medication as directed by your health care provider. Avoiding allergy triggers can also help you prevent flare-ups.

  • Keep an eczema journal. This can help you track your symptoms and identify eczema triggers.
  • Stay away from skin irritants. Common irritants include wool, soaps and detergents, perfume, chemicals, sand, and cigarette smoke.
  • Avoid allergens. Pollen, mold, animal dander, dust mites and other allergens may trigger eczema flares. Avoid these substances by using dust-proof mattress and pillow covers, removing carpeting, avoiding contact with animals, and staying indoors when pollen counts are high.
  • Consider food allergies in children. If you suspect you child has food allergies, ask about having your child tested. Children need a wide range of foods to grow healthy and strong, so don't limit your child's food choices without first talking with your doctor.