Addison’s disease. Hyperpigmentation representing an accentuation of normal pigmentation of the hand of a patient with Addison’s disease (left). For comparison, the hand of a normal individual, matched for ethnic pigmentation, is shown on the right.
Drug-induced pigmentation: amiodarone A striking slate-gray pigmentation in a photodistribution of the face. The blue color (ceruloderma) is due to the deposition of melanin and lipofuscin contained in macrophages and endothelial cells in the dermis. The pigmentation is reversible, but it may take up to a year or more to complete resolution. In this patient it took 33 months for the ceruloderma to disappear.
Allergic contact dermatitis (reaction to temporary tattoo). Contact allergy to temporary tattoos has become an increasingly common phenomenon. In most cases, the tattoo material does not contain pure henna, but is a mixture of brown henna with paraphenylenediamine (PPD) called black henna. The patient is allergic to PPD in the tatto. In fact, the concentration of PPD in black henna is higher than that seen in commercial hair dyes. After resolution of the eczematous skin eruption, postinflammatory hyperpigmentation may persist for a considerable period of time.