Some experts find that even when nonprescription topical products are used frequently-every 2 hours while a person is awake-at the first sign of an outbreak, they may only speed recovery time by a few hours or a day.2
Prescription creams and ointments
Penciclovir cream (Denavir) is an antiviral cream that may reduce healing time by 1 to 2 days, especially if the cold sore was triggered by sunlight exposure. It also reduces the pain, itching, burning, and tenderness of cold sores.1
Acyclovir ointment or cream works best if it is used at the first sign of cold sore symptoms. Side effects of the ointment may include mild pain or stinging at the site where it is applied.
The U.S. Food and Drug Administration (FDA) approved acyclovir cream to treat recurrent cold sores in people older than age 12. The cream can improve healing time by up to half a day. The cream may cause temporary skin irritation.
Nonprescription creams and ointments
Tetracaine cream (Viractin) and lidocaine (Zilactin-L) are topical anesthetics that can relieve the pain and itching of cold sores. These products are applied to cold sores up to 6 times a day for best results. Pain and itching are relieved usually within 2 to 3 days after a person first applies the product.
Docosanol 10% (Abreva) should be applied at the first signs of a cold sore outbreak. It is the first nonprescription cold sore medicine approved by the U.S. Food and Drug Administration (FDA) to shorten healing time and the duration of symptoms.
Benzyl alcohol (Zilactin) is a gel that relieves the pain of cold sores and may help shorten healing time, especially if it is used as soon as a cold sore begins to form.
Dimethicone with sunscreen (Herpecin-L) is a product that moisturizes your lips and protects them from the sun. This can help reduce the pain and itching of cold sores. It can also help prevent cold sores from returning, especially if they were triggered by sun exposure.
Cold sores usually heal on their own without prescription medicines or complementary therapies.