Drugs to Treat Bedwetting

If no underlying medical condition is causing your child's bed wetting, there is no real medical need to treat him. Bedwetting tends to go away by itself. However, if after talking to your child's doctor you decide to treat your child with medications, several drug therapies are available.

The two drugs approved by the FDA specifically for bedwetting are DDAVP and Tofranil. Other medications used to treat bedwetting, which are not specifically approved for it, include Ditropan and Levsin.

Drug therapy does not work for everyone, and these medications can have significant side effects. Talk to your child's doctor to determine if drug therapy is right for your child.

A Guide to Bedwetting Drugs

Here's an overview of each drug used to treat bedwetting:

DDAVP

DDAVP is a synthetic form of antidiuretic hormone (ADH), a substance that occurs naturally in the body. This drug works by imitating ADH in the body, which increases the concentration of the urine and reduces the amount of urine. Its main use is for children who have not been helped by an alarm. It is also used as a stopgap measure to help children attend camps or sleepovers without embarrassment. It is an FDA-approved treatment for bedwetting.

DDAVP comes as a nasal spray or pill and is taken before bedtime. The dose is adjusted until effective. Once it is working, the dose is tapered, if possible.

Side effects of DDAVP are uncommon but may include:

• Headache
• Runny nose
• Nasal stuffiness
• Nose bleeds

Tofranil

Tofranil is a tricyclic antidepressant that has been used to treat bedwetting for about 30 years. How it works is not clear, but it is known to have a relaxing effect on the bladder, allowing the bladder to hold more urine comfortably.

Side effects of Tofranil tend to be rare with correct dosage but may include:

• Nervousness
• Anxiety
• Constipation
• Personality changes

Warning

Tofranil can have toxic side effects if taken improperly. Deaths have been attributed to accidental overdoses.

Ditropan and Levsin

Ditropan and Levsin work by reducing unwanted bladder contractions. Side effects may include:

• Dry mouth
• Drowsiness
• Flushing
• Heat sensitivity
• Constipation