Jan. 25, 2010 (Orlando, Fla.) -- A pill that cuts off the supply of nutrients to tumors shows promise for treating people with the rare type of pancreatic cancer that afflicted Apple CEO Steve Jobs.
Cancer progressed in 5.5 months among patients on placebo vs. 11.4 months among patients on Sutent. Sutent also cut the risk of dying by 60%, says Eric Raymond, MD, head of medical oncology at the Hospital Beaujon in Clichy, France.
The findings were presented at the 2010 Gastrointestinal Cancers Symposium (GCS).
"For the first time in 18 years, [a new drug] has demonstrated benefit in these patients," Raymond tells WebMD.
"Even though they are rare, these tumors are a life-limiting event for patients who have them. This is a very strong study," says Richard M. Goldberg, MD, head of the North Carolina Cancer Hospital in Chapel Hill.
"I am hopeful it will change how we treat these patients," says Goldberg, who was not involved with the research.
Sutent Cuts Blood Supply to Tumors
If diagnosed early, neuroendocrine tumors can often be surgically removed before they have spread throughout the body, experts say.
Neuroendocrine tumors also grow more slowly than other pancreatic tumors. "But once they progress, they can progress quickly," Raymond says.
People with advanced neuroendocrine tumors have very few options, he says. There's chemotherapy, but that requires a hospital stay and causes a host of side effects from extreme vomiting and nausea to hair loss. Only about one in three patients benefit, Raymond says.
Sutent is part of a class of drugs called tyrosine kinase inhibitors. It is already approved to treat advanced kidney cancer and recalcitrant gastrointestinal stromal tumors (GIST).
In the new study, patients with advanced pancreatic neuroendocrine tumors took either three Sutent capsules every morning or placebo pills. All were also given medication to treat pain and diarrhea as needed.
"The adverse events were generally tolerable and manageable with a drug holiday or dose reduction," Raymond says.
The study was sponsored by Pfizer, which makes Sutent.