If you are:
Not Recommended: BASED ON DRUG PHARMACOLOGY MAY CAUSE FETAL HARM
Absolute Contraindication: EXCRETED IN RAT STUDIES;MFR REC DISCONTINUING BREASTFEEDING DURING THERAPY.
An adult over 60:
management or monitoring precaution: General-The starting dose of Irinotecan in patients 70 years and older for the every-3-week-dosage schedule should be 300 mg/m2. The incidence of severe diarrhea and neutropenia is higher in the elderly.
Giving irinotecan HCL Vial to a child under 12:
Severe Precaution: Risk of dehydration, hypokalemia, hyponatremia. Efficacy not demonstrated in pediatric trials.