Does FOSPHENYTOIN SODIUM Interact with other Medications?

Severe Interactions

These medications are not usually taken together. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation.

  • FOSPHENYTOIN; PHENYTOIN/AZAPROPAZONE
  • DUAL STRONG OR MODERATE CYP2C19 & CYP3A4 INDUCERS/MAVACAMTEN
  • STRONG CYP3A4 INDUCERS/PACRITINIB
  • UGT1A1 INDUCERS/CABOTEGRAVIR
  • CYP3A4 & UGT1A1 INDUCERS/CABOTEGRAVIR-RILPIVIRINE
  • STRONG AND MODERATE CYP3A4 INDUCERS/LONAFARNIB
  • STRONG CYP3A4 INDUCERS/FOSTEMSAVIR
  • STRONG CYP3A4 INDUCERS/TAMOXIFEN
  • STRONG CYP3A4 INDUCERS/LORLATINIB
  • CYP3A4 INDUCERS/DORAVIRINE
  • SELECTED CYP3A4 INDUCERS/ATAZANAVIR-COBICISTAT
  • STR CYP3A4 & P-GP INDUCER;PHENOBARB/GLECAPREVIR-PIBRENTASVIR
  • SELECTED CYP3A4 INDUCERS/COBICISTAT-ELVITEGRAVIR
  • STRONG CYP3A4 INDUCERS/ELBASVIR-GRAZOPREVIR
  • PHENYTOIN/ISAVUCONAZONIUM
  • STRONG CYP3A4 INDUCERS/DELAMANID
  • SLT MODERATE-STRONG CYP3A4 INDUCERS/SLT HEPATITIS C AGENTS
  • STRONG CYP3A4 INDUCERS/DACLATASVIR
  • P-GP INDUCERS; PHENOBARBITAL/SELECTED HEPATITIS C AGENTS
  • STRONG CYP3A4 INDUCERS/ARTEMETHER; LUMEFANTRINE
  • SELECT CYP3A4 INDUCERS/RILPIVIRINE
  • CYP3A4 INDUCERS/SELECTED PROTEASE INHIBITORS; COBICISTAT
  • STRONG CYP3A4 INDUCERS/TICAGRELOR; VORAPAXAR
  • STRONG CYP3A4 INDUCERS/LURASIDONE
  • SELECTED STRONG CYP3A4 INDUCERS/PRAZIQUANTEL
  • STRONG CYP3A4 INDUCERS/RANOLAZINE
  • SLT STRONG 3A4 INDUCERS/NIFEDIPINE; NIMODIPINE; NISOLDIPINE
  • SELECTED STRONG CYP3A4 INDUCERS/DELAVIRDINE; ETRAVIRINE
  • Serious Interactions

    These medications may interact and cause very harmful effects. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation.

  • HYDANTOINS/SELECTED ANTICOAGULANTS (VITAMIN K ANTAGONISTS)
  • SELECTED ANTICONVULSANTS; BARBITURATES/CONTRACEPTIVES
  • HYDANTOINS/RIFAMYCINS
  • SELECTED ANTICONVULSANTS; BARBITURATES/TELITHROMYCIN
  • PHENYTOIN/SULTHIAME
  • HYDANTOINS/FLUOROURACIL & FLUOROURACIL PRODRUGS
  • SELECTED ANTICONVULSANTS; BARBITURATES/SLT AZOLE ANTIFUNGALS
  • BARBITURATES;PHENOBARBITAL;PHENYTOIN/SLT PROTEASE INHIBITORS
  • SELECT CYP2C8; 2C9 SUBSTRATES/MIFEPRISTONE (CHRONIC THERAPY)
  • HYDANTOINS/FLUVOXAMINE
  • PHENYTOIN/CENOBAMATE
  • SELECTED CYP2C9 SUBSTRATES/ASCIMINIB
  • SELECTED STRONG CYP3A4 INDUCERS/DRONEDARONE
  • STRONG CYP3A4 INDUCERS/SAVOLITINIB
  • STR OR MOD 3A4 INDUCER/VONOPRAZAN-CLARITHROMYCIN-AMOXICILLIN
  • STRONG OR MODERATE CYP3A4 INDUCERS/VONOPRAZAN
  • STRONG CYP3A4 INDUCERS/ALPELISIB
  • STRONG OR MODERATE CYP3A4 INDUCERS/GANAXOLONE
  • STRONG CYP3A4 INDUCERS/MITAPIVAT
  • STRONG CYP3A4 INDUCERS/CYCLOPHOSPHAMIDE
  • FOSPHENYTOIN; PHENYTOIN/RIVOCERANIB
  • STRONG CYP3A4 INDUCERS/LEVOKETOCONAZOLE
  • STRONG CYP3A4 INDUCERS/TADALAFIL (BPH, PAH)
  • SELECTED ANTICONVULSANTS/MARIBAVIR
  • STRONG CYP3A4 INDUCERS/SURUFATINIB
  • STRONG OR MODERATE CYP3A4 INDUCERS/AVACOPAN
  • STRONG OR MODERATE CYP3A4 INDUCERS/MOBOCERTINIB
  • STRONG AND MODERATE CYP3A4 INDUCERS/FEXINIDAZOLE
  • STRONG AND MODERATE CYP3A4 INDUCERS/FINERENONE
  • STRONG AND MODERATE CYP3A4 INDUCERS/IBREXAFUNGERP
  • STRONG CYP3A4 INDUCERS/SAMIDORPHAN
  • STRONG AND MODERATE CYP3A4 INDUCERS/INFIGRATINIB
  • STRONG CYP3A4 INDUCERS/SOTORASIB
  • DUAL P-GP & STRONG 3A4 INDUC/RELUGOLIX-HORMONAL COMBINATIONS
  • PHENYTOIN/EFAVIRENZ
  • FOSPHENYTOIN; PHENYTOIN/ENZALUTAMIDE
  • SELECTED STRONG CYP3A4 INDUCERS/APREPITANT; NETUPITANT
  • STRONG CYP3A4 INDUCERS/TEPOTINIB
  • STRONG AND MODERATE CYP3A4 INDUCERS/VOCLOSPORIN
  • P-GP AND STRONG CYP3A4 INDUCERS/RELUGOLIX
  • STRONG CYP3A4 INDUCERS/LUMACAFTOR-IVACAFTOR
  • STRONG CYP3A4 INDUCERS/PRALSETINIB
  • STRONG CYP3A4 INDUCERS/PLITIDEPSIN
  • SELECTED UGT1A1 INDUCERS/RALTEGRAVIR
  • STRONG CYP1A2, CYP2B6 OR CYP3A4 INDUCERS/FENFLURAMINE
  • STRONG AND MODERATE CYP3A4 INDUCERS/LURBINECTEDIN
  • STRONG CYP3A4 INDUCERS/RIPRETINIB
  • STRONG AND MODERATE CYP3A4 INDUCERS/SELPERCATINIB
  • STRONG AND MODERATE CYP3A4 INDUCERS/CAPMATINIB
  • UGT1A1 INDUCERS/SACITUZUMAB GOVITECAN
  • STRONG CYP3A4 INDUCERS; MODERATE CYP2C8 INDUCERS/TUCATINIB
  • STRONG AND MODERATE CYP3A4 INDUCERS/PEMIGATINIB
  • STRONG AND MODERATE CYP3A4 INDUCERS/SELUMETINIB
  • STRONG AND MODERATE CYP3A4 INDUCERS/RIMEGEPANT
  • STRONG OR MODERATE CYP3A4 INDUCERS/TAZEMETOSTAT
  • STRONG CYP3A4 INDUCERS/REGORAFENIB
  • STRONG OR MODERATE CYP3A4 INDUCERS/AVAPRITINIB
  • CYP3A4 INDUCERS/LUMATEPERONE
  • STRONG OR MODERATE CYP3A4 INDUCERS/DARIDOREXANT; LEMBOREXANT
  • STRONG CYP3A4 INDUCERS/UBROGEPANT
  • SELECTED STRONG OR MODERATE CYP3A4 INDUCERS/VOXELOTOR
  • STRONG OR MODERATE CYP3A4 INDUCERS/ZANUBRUTINIB
  • P-GLYCOPROTEIN (P-GP) OR UGT INDUCERS/LETERMOVIR
  • SELECTED STRONG CYP3A4 INDUCERS/ISTRADEFYLLINE
  • STRONG CYP3A4 OR P-GLYCOPROTEIN (P-GP) INDUCER/LEFAMULIN
  • STRONG CYP3A4 INDUCERS/FEDRATINIB
  • STRONG CYP3A4 INDUCERS/UPADACITINIB
  • STRONG CYP3A4 INDUCERS/ENTRECTINIB
  • STRONG AND MODERATE CYP3A4 INDUCERS/PRETOMANID
  • STRONG CYP3A4 INDUCERS/PEXIDARTINIB
  • P-GP AND STRONG CYP3A4 INDUCERS/DAROLUTAMIDE
  • SELECTED STRONG CYP3A4 INDUCERS; RIFABUTIN/BICTEGRAVIR
  • STRONG CYP3A4 INDUCERS/TIVOZANIB
  • STRONG CYP3A4 INDUCERS/ERDAFITINIB
  • PHENYTOIN/VORICONAZOLE
  • SELECTED MODERATE AND STRONG CYP3A4 INDUCERS/SIPONIMOD
  • P-GP AND STRONG CYP3A4 INDUCERS/GILTERITINIB
  • STRONG CYP3A4 INDUCERS; RIFABUTIN/LAROTRECTINIB
  • STRONG CYP3A4 INDUCERS/GLASDEGIB
  • STRONG CYP3A4 INDUCERS/DUVELISIB
  • STRONG CYP3A4 INDUCERS/ERAVACYCLINE
  • STRONG CYP3A4 INDUCERS/IVOSIDENIB
  • STRONG CYP3A4 INDUCER/SLT LONG-ACTING ARIPIPRAZOLE INJECTION
  • STRONG AND MODERATE CYP3A4 INDUCERS/ENCORAFENIB
  • STRONG CYP3A4 INDUCERS/FOSTAMATINIB
  • STRONG CYP3A4 INDUCERS/MACIMORELIN
  • STRONG CYP3A4 INDUCERS/ACALABRUTINIB
  • STRONG CYP3A4 INDUCERS/ABEMACICLIB
  • STRONG CYP3A4 INDUCERS/COPANLISIB
  • STRONG AND MODERATE CYP3A4 INDUCERS/NERATINIB
  • P-GLYCOPROTEIN (P-GP) INDUCERS/ETOPOSIDE
  • STRONG CYP3A4 INDUCERS; RIFABUTIN/BRIGATINIB
  • STRONG CYP3A4 INDUCERS/MIDOSTAURIN
  • STRONG CYP3A4 INDUCERS/VALBENAZINE
  • STRONG CYP3A4 INDUCERS/NALDEMEDINE
  • STRONG CYP3A4 INDUCERS/RIBOCICLIB
  • STRONG AND MODERATE CYP3A4 INDUCERS/PIMAVANSERIN
  • STRONG CYP3A4 INDUCERS/VENETOCLAX
  • STRONG CYP3A4 INDUCERS; RIFABUTIN/VEMURAFENIB
  • STRONG CYP3A4 INDUCERS/TOFACITINIB
  • SLT MODERATE AND STRONG CYP3A4 INDUCERS/IXAZOMIB
  • STRONG CYP3A4 INDUCERS/OSIMERTINIB
  • STRONG CYP3A4 INDUCERS/TRABECTEDIN
  • STRONG CYP3A4 INDUCERS/FLIBANSERIN
  • STRONG CYP3A4 INDUCERS/SELECTED ANTINEOPLASTICS
  • STRONG CYP3A4 INDUCERS/NALOXEGOL
  • P-GP AND STRONG CYP3A4 INDUCERS/NINTEDANIB
  • STRONG CYP3A4 INDUCERS/ELIGLUSTAT
  • STRONG CYP3A4 INDUCERS/RAMELTEON; SUVOREXANT; TASIMELTEON
  • STRONG CYP3A4 INDUCERS/QUETIAPINE (> 150 MG)
  • STRONG & MODERATE CYP3A4 INDUCERS/GUANFACINE
  • STRONG OR MODERATE CYP3A4 INDUCERS/SIMEPREVIR
  • SELECTED UGT1 & CYP3A4 INDUCERS/DOLUTEGRAVIR
  • UGT INDUCERS/CANAGLIFLOZIN
  • STRONG & MODERATE CYP3A4 INDUCERS/BEDAQUILINE
  • STRONG CYP3A4 INDUCERS; RIFABUTIN/PONATINIB
  • SELECTED STRONG CYP3A4 INDUCERS/BORTEZOMIB
  • STRONG CYP3A4 INDUCERS/IVACAFTOR
  • STRONG & MODERATE CYP3A4 INDUCERS/SELECTED ANTINEOPLASTICS
  • P-GP & STRONG 3A4 INDUCERS;EFAVIRENZ;PB/APIXABAN;RIVAROXABAN
  • STRONG CYP3A4 INDUCERS/TOREMIFENE
  • STRONG P-GP OR CYP3A4 INDUCER/LINAGLIPTIN
  • P-GLYCOPROTEIN (P-GP) INDUCERS/DABIGATRAN
  • STRONG CYP3A4 INDUCERS/APREMILAST; ROFLUMILAST
  • SELECTED STRONG CYP3A4 INDUCERS/IXABEPILONE
  • STRONG CYP3A4 INDUCERS; RIFABUTIN/ROMIDEPSIN
  • STRONG UGT INDUCERS/DEFERASIROX
  • SELECTED STRONG CYP3A4 INDUCERS/ULIPRISTAL
  • SELECTED STRONG CYP3A4 INDUCERS/AMIODARONE
  • STRONG CYP3A4 INDUCERS/TOLVAPTAN
  • STRONG CYP3A4 INDUCERS/SELECTED IMMUNOSUPPRESSANTS
  • SELECTED ANTICONVULSANTS; BARBITURATES/FESOTERODINE
  • STRONG CYP3A4 INDUCERS/MARAVIROC
  • STRONG CYP3A4 INDUCERS/MACITENTAN
  • SELECTED STRONG CYP3A4 INDUCERS/IRINOTECAN
  • SELECTED STRONG CYP3A4 INDUCERS/DARUNAVIR
  • SELECTED ANTICONVULSANTS/POSACONAZOLE
  • STRONG 3A4 INDUCERS/SLT ANTINEOPLASTIC SYSTEMIC ENZYME INHIB
  • STRONG CYP3A4 INDUCERS/IVABRADINE
  • STRONG CYP3A4 INDUCERS/EXEMESTANE
  • STRONG CYP3A4 INDUCERS/SELECTED ANTIPSYCHOTICS
  • STRONG CYP3A4 INDUCERS/ROLAPITANT
  • PHENYTOIN/TOPOTECAN
  • SELECTED CYP1A2 AND CYP3A4 INDUCERS/CLOZAPINE
  • HYDANTOINS/CHLORAMPHENICOL
  • HYDANTOINS/DISULFIRAM
  • STR 3A4 INDUCER;SLT BARBITURATES,HYDANTOIN/SLT ANTIMALARIALS
  • Moderate Interactions

    These medications may cause some risk when taken together. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation.

  • HYDANTOINS/ISONIAZID
  • HYDANTOINS/FOLIC ACID; PYRIMETHAMINE
  • HYDANTOINS/CIMETIDINE; RANITIDINE
  • HYDANTOINS/SELECTED SULFONAMIDE ANTIBACTERIALS; TRIMETHOPRIM
  • HYDANTOINS/OMEPRAZOLE
  • HYDANTOINS/FLUOXETINE
  • HYDANTOINS/SELECTED ANTINEOPLASTICS
  • SELECTED ANTICONVULSANTS; BARBITURATES/ESTROGENS
  • FOSPHENYTOIN; PHENYTOIN/CIPROFLOXACIN
  • HYDANTOINS/ETHYL ALCOHOL
  • HYDANTOINS/SELECT NEUROMUSCULAR BLOCKING AGENTS
  • PHENYTOIN/FLUVASTATIN
  • SELECTED CYP2C9 SUBSTRATES/NITISINONE
  • SELECTED CYP2C9 SUBSTRATES/LORLATINIB
  • STRONG AND MODERATE CYP3A4 INDUCERS/ATOGEPANT
  • STRONG CYP3A4 INDUCERS/BELUMOSUDIL
  • PHENYTOIN/MEXILETINE
  • SLT DUAL CYP2C19 & CYP3A4 INDUCERS/CITALOPRAM; ESCITALOPRAM
  • SELECTED STRONG CYP3A4 INDUCERS/HALOPERIDOL
  • SELECTED P-GP INDUCERS/BEROTRALSTAT
  • STRONG UGT INDUCERS; NEVIRAPINE/ARTESUNATE
  • SELECTED STRONG CYP3A4 INDUCERS/LEVOMETHADYL
  • CYP2B6 AND SELECTED CYP3A4 INDUCERS/LEVOMETHADONE; METHADONE
  • STRONG CYP3A4 INDUCERS/CANNABIDIOL; TETRAHYDROCANNABINOL
  • STRONG CYP3A4 INDUCERS/PITOLISANT
  • SELECTED P-GLYCOPROTEIN (P-GP) INDUCERS/BETRIXABAN
  • SODIUM CHANNEL BLOCKER; POTASSIUM CHANNEL BLOCKER/LACOSAMIDE
  • PHENYTOIN; ANTICONVULSANT BARBITURATES/SLT ANTICONVULSANTS
  • PHENYTOIN; ANTICONVULSANT BARBITURATES/LAMOTRIGINE
  • PHENYTOIN; ANTICONVULSANT BARBITURATES/ESLICARBAZEPINE
  • STRONG CYP2C19 AND CYP3A4 INDUCERS/LANSOPRAZOLE
  • STRONG AND MODERATE CYP3A4 INDUCERS/PERAMPANEL
  • SELECTED CYP1A2 INDUCERS/OLANZAPINE
  • SELECTED STRONG CYP3A4 INDUCERS/CLARITHROMYCIN; ERYTHROMYCIN
  • SELECTED P-GP INDUCERS; PHENOBARBITAL/TENOFOVIR ALAFENAMIDE
  • SELECTED P-GLYCOPROTEIN (P-GP) INDUCERS/EDOXABAN
  • STRONG CYP3A4 INDUCERS/VILAZODONE
  • P-GLYCOPROTEIN (P-GP) INDUCERS; PHENOBARBITAL/AFATINIB
  • SELECTED CYP3A4 INDUCERS/SELECTED BENZODIAZEPINES
  • STRONG CYP3A4 INDUCERS/SELECT SEDATIVE HYPNOTICS; BUSPIRONE
  • SELECTED STRONG CYP3A4 INDUCERS/TIRILAZAD
  • FOSPHENYTOIN; PHENYTOIN/CASPOFUNGIN
  • SELECTED ANTICONVULSANTS; BARBITURATES/FELODIPINE
  • BARBITURATES; HYDANTOINS/THEOPHYLLINE
  • HYDANTOINS/PRIMIDONE
  • HYDANTOINS/DIGITALIS GLYCOSIDES
  • SELECTED STRONG CYP3A4 INDUCERS/SELECTED OPIOIDS
  • HYDANTOINS/METYRAPONE
  • HYDANTOINS/SULFINPYRAZONE
  • PHENYTOIN; ANTICONVULSANT BARBITURATES/CARBAMAZEPINE
  • CYP3A4 INDUCERS/DOXYCYCLINE
  • SELECTED CYP3A4 INDUCERS/CORTICOSTEROIDS
  • Drug Survey

    Are you currently using fosphenytoin injection?

    This survey is being conducted by the WebMD marketing sciences department.

    Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

    CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.