Ergot Alkaloids/Itraconazole; Ketoconazole Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Very Serious. These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
When these two medicines are taken together, your body may not process ergot alkaloids properly.
What might happen:
Your blood levels of the ergot alkaloid may increase and cause toxic effects.
What you should do about this interaction:
Contact your healthcare professional (e.g. doctor or pharmacist) right away about using these medicines together. Your doctor may not want you to take any ergot alkaloids while you are taking your antifungal.If you experience chest pain; change in heartbeat; numbness and tingling of hands, feet, or face; pain in arms, legs, or lower back; itching; or other symptoms while taking both of these medicines, contact your doctor.Your healthcare professionals (e.g. doctor or pharmacist) may already be aware of this drug interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
- 1.Sporanox (itraconazole) US prescribing information. Janssen Pharmaceutica Products, L.P. May, 2018.
- 2.Methergine (methylergonovine maleate) US prescribing information. Novartis Pharmaceuticals Corporation June, 2012.
- 3.D. H. E. 45 (dihydroergotamine mesylate) US prescribing information. Valeant Pharmaceuticals North America November 6, 2017.
- 4.Cafergot (ergotamine tartrate and caffeine) tablets US prescribing information. Sandoz Inc May 14, 2012.
- 5.Nizoral (ketoconazole oral) US prescribing information. Janssen Pharmaceuticals February, 2014.
- 6.Phansalkar S, Desai AA, Bell D, Yoshida E, Doole J, Czochanski M, Middleton B, Bates DW. High-priority drug-drug interactions for use in electronic health records. J Am Med Inform Assoc 2012 Sep-Oct; 19(5):735-43.
- 7.Christensen J, Dupont E, OStergaard K. Cabergoline plasma concentration is increased during concomitant treatment with itraconazole. Mov Disord 2002 Nov;17(6):1360-2.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.