This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Antacids and supplements that contain aluminum and/or magnesium may bind to raltegravir in your GI tract.
What might happen:
Your body may not absorb the full dose of your raltegravir and it may not work as well.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Your doctor may want to run some blood tests to check how your medicine is working. If you need an antacid and are taking raltegravir more than once daily, you may use one that contains calcium carbonate instead of aluminum or magnesium. Ask your pharmacist if you need help selecting an antacid.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Isentress (raltegravir) US prescribing information. Merck & CO., Inc. May 26, 2017.
2.Krishna R, East L, Larson P, Valiathan C, Butterfield K, Teng Y, Hernandez-Illas M. Effect of metal-cation antacids on the pharmacokinetics of 1200 mg raltegravir. J Pharm Pharmacol 2016 Nov;68(11):1359-1365.
3.Moss DM, Siccardi M, Back DJ, Owen A. Predicting intestinal absorption of raltegravir using a population-based ADME simulation. J Antimicrob Chemother 2013 Jul;68(7):1627-34.
4.Moss DM, Siccardi M, Murphy M, Piperakis MM, Khoo SH, Back DJ, Owen A. Divalent metals and pH alter raltegravir disposition in vitro. Antimicrob Agents Chemother 2012 Jun;56(6):3020-6.