Slt Anticoagulants (Vit K Antagonists)/Topical Salicylates Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

When these two medicines are used together, aspirin or similar medicine may decrease the ability of your blood to clot properly and/or may cause stomach irritation.

What might happen:

You may experience an increased chance for bleeding. Symptoms may include: bleeding from your gums, nosebleeds, unusual bruising, red or orange urine, severe headache, coughing up blood, blood in vomit, or dark/black/tarry stools.

What you should do about this interaction:

Ask your healthcare professionals (e.g. doctor or pharmacist) about taking these medicines together. They may recommend a non-aspirin product. If your doctor prescribes these medicines together, you may need to have laboratory testing more often. Do not use more than the prescribed or recommended amount of your topical salicylate product.If you have any signs of bleeding such as bleeding from your gums, nosebleeds, unusual bruising, red or orange urine, severe headache, coughing up blood, blood in vomit, or dark/black/tarry stools contact your doctor right away.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Yip AS, Chow WH, Tai YT, Cheung KL. Adverse effect of topical methylsalicylate ointment on warfarin anticoagulation: an unrecognized potential hazard. Postgrad Med J 1990 May;66(775):367-9.
  • 2.Chow WH, Cheung KL, Ling HM, See T. Potentiation of warfarin anticoagulation by topical methylsalicylate ointment. J R Soc Med 1989 Aug;82(8):501-2.
  • 3.Joss JD, LeBlond RF. Potentiation of warfarin anticoagulation associated with topical methyl salicylate. Ann Pharmacother 2000 Jun;34(6):729-33.
  • 4.Chan TY. Potential dangers from topical preparations containing methyl salicylate. Hum Exp Toxicol 1996 Sep;15(9):747-50.
  • 5.Ramanathan M. Warfarin--topical salicylate interactions: case reports. Med J Malaysia 1995 Sep;50(3):278-9.
  • 6.Tam LS, Chan TY, Leung WK, Critchley JA. Warfarin interactions with Chinese traditional medicines: danshen and methyl salicylate medicated oil. Aust N Z J Med 1995 Jun;25(3):258.
  • 7.Littleton F Jr. Warfarin and topical salicylates. JAMA 1990 Jun 6; 263(21):2888.
  • 8.Zhou M, Leonard CE, Brensinger CM, Bilker WB, Kimmel SE, Hecht TEH, Hennessy S. Pharmacoepidemiologic Screening of Potential Oral Anticoagulant Drug Interactions Leading to Thromboembolic Events..

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.