What is Repatha used for?

Repatha (evolocumab) is commonly used for the following conditions. 

Repatha may also be used for other conditions as determined by your healthcare provider.

How does Repatha work (mechanism of action)?

Repatha works by binding to and blocking an enzyme in the body called PCSK9. This enzyme breaks down receptors in the liver that help remove bad cholesterol (LDL-C) from the blood. By blocking the PCSK9 enzyme, the receptors in the liver can remove more bad cholesterol from the blood. This can help decrease your risk of heart disease, stroke, and heart attack. 

How is Repatha supplied (dosage forms)?

Repatha is available in the following dosage forms that are injected under the skin.

  • 140 mg/mL injection (prefilled syringe)
  • 140 mg/mL injection (SureClick prefilled autoinjector)
  • 420 mg/3.5 mL injection (Pushtronex system)

How should I store Repatha?

Repatha can be stored in a refrigerator, between 36 F to 46 F (2 C to 8 C) until the expiration date on the label or at room temperature, between 68 F to 77 F (20 C to 25 C) for up to 30 days. Do not freeze.

Do not use the medicine if left out of the refrigerator for more than 30 days. Keep the medicine in its original package to protect it from light until you want to use it. Do not shake.

Side Effects

What are the most common side effects of Repatha?

The most common side effects of Repatha are listed below. Tell your healthcare provider if you have any of these side effects that bother you.

  • Infection in the nose or throat, sore throat, or common cold symptoms
  • Flu symptoms 
  • Back pain
  • Pain, bruising, or redness near the injection site 
  • High blood sugar

There may be other side effects of Repatha that are not listed here. Contact your healthcare provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at or by calling 800-FDA-1088. In Canada, you can report side effects to Health Canada at or by calling 866-234-2345.

What are the serious side effects of Repatha?

While less common, the most serious side effects of Repatha are described below, along with what to do if they happen.

Severe Allergic Reactions. Repatha may cause allergic reactions, which can be serious. Stop using Repatha and get help right away if you have any of the following symptoms of a serious allergic reaction.

  • Breathing problems or wheezing
  • Racing heart
  • Fever or general ill feeling
  • Swollen lymph nodes
  • Swelling of the face, lips, mouth, tongue, or throat
  • Trouble swallowing or throat tightness
  • Itching, skin rash, or pale red bumps on the skin called hives
  • Nausea or vomiting
  • Dizziness, feeling lightheaded, or fainting
  • Stomach cramps
  • Joint pain

Warnings & Precautions

Who should not use Repatha?

Allergies to Ingredients. People who are allergic to any of the following should not use Repatha.

  • Repatha
  • Evolocumab
  • Any of the ingredients in the specific product dispensed

Your pharmacist can tell you all of the ingredients in Repatha.

What should I know about Repatha before using it?

Do not use Repatha unless it has been prescribed to you by a healthcare provider. Use it as prescribed. This medicine is injected under the skin. Make sure that you or a caregiver understands how to properly prepare and use Repatha. If you have any questions, talk to your healthcare provider.

Do not use the same exact spot for each injection. Do not inject into any painful areas or where your skin is thickened, bruised, red, or swollen.

Do not share Repatha with other people, even if they have the same condition as you. It may harm them.

Keep Repatha out of the reach of children. Since this medicine may be kept in a refrigerator, take special precautions to keep it away from children who also use the refrigerator.

The needle covers of both the glass single-dose prefilled syringe and single-dose prefilled autoinjector contain dry natural rubber, which is made from latex. An allergic reaction may happen if you are sensitive to latex.

What should I tell my healthcare provider before using Repatha?

Tell your healthcare provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them determine if Repatha is right for you.

In particular, make sure that you discuss if you have an allergy to rubber or latex.

Pregnancy. It is not known if or how Repatha could affect pregnancy or harm an unborn baby. Tell your healthcare provider if you are or plan to become pregnant. A study is being conducted to collect safety information. If you become pregnant, you are encouraged to report your pregnancy to the manufacturer by calling 800-772-6436. 

Breastfeeding. It is not known if Repatha passes into breast milk. Tell your healthcare provider if you are breastfeeding or plan to breastfeed. Your healthcare provider will advise you if you should use Repatha while breastfeeding.

How can I get more information about Repatha?

For more information about Repatha, you can visit the manufacturer’s website at or call them at 844-737-2842.


Does Repatha interact with foods or drinks?

There are no known interactions between Repatha and foods or drinks.

It is unknown if drinking alcohol will affect Repatha.

Does Repatha interact with other medicines (drug interactions)?

There are no known interactions between Repatha and other medicines. Always tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.

Does Repatha (evolocumab) interact with other drugs you are taking?
Enter your medication into the WebMD interaction checker

Overdose/Missed Dose

What should I do if I accidentally use too much Repatha?

If you or someone else has used too much Repatha, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.

What should I do if I miss a dose of Repatha?

If you miss a dose, take it as soon as you remember if it is within 7 days of the scheduled dose. If it is more than 7 days after your scheduled time, wait to take your dose at the regular scheduled time if you take it every 2 weeks. If you take Repatha monthly and more than 7 days have passed since your scheduled dose, take your dose and start a new schedule with this date. Do not take double or extra doses.

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