Uses

Consult your pharmacist or physician.

How to use Paxlovid (EUA) 300 Mg (150 X 2)-100 Tablet Pharmacoenhancer - Cytochrome P450 Inhibitors

tablet that is swallowed

Side Effects

What are the most common side effects of Paxlovid?

The most common side effects of Paxlovid are listed below. Tell your healthcare provider if you have any of these side effects that bother you.

  • Change in how things taste
  • Diarrhea
  • Headache
  • Nausea and vomiting
  • Stomach pain
  • High blood pressure
  • Overall unwell feeling

There may be other side effects of Paxlovid that are not listed here. Contact your healthcare provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088. In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.

What are the serious side effects of Paxlovid?

While less common, the most serious side effects of Paxlovid are described below, along with what to do if they happen.

Severe Allergic Reactions. Paxlovid may cause allergic reactions, which can be serious. Stop taking Paxlovid and get help right away if you have any of the following symptoms of a serious allergic reaction.

  • Breathing problems or wheezing
  • Racing heart
  • Fever or general ill feeling
  • Swollen lymph nodes
  • Swelling of the face, lips, mouth, tongue, or throat
  • Trouble swallowing or throat tightness
  • Itching, skin rash, or pale red bumps on the skin called hives
  • Nausea or vomiting
  • Dizziness, feeling lightheaded, or fainting
  • Stomach cramps
  • Joint pain

Severe Skin Reactions. Paxlovid can cause severe skin reactions called Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) that can lead to death if not treated. If you develop a rash, stop Paxlovid and call your healthcare provider right away. Get emergency help right away if you have any of the following symptoms of SJS or TEN.

  • Painful red or purple skin that looks burned and peels off
  • Flat red rash or blisters on your skin, mouth, nose, and genitals
  • Red, painful, watery eyes

Liver Damage. Liver damage, also called hepatotoxicity, can happen when taking Paxlovid. Call your healthcare provider right away if you have any of the following symptoms of liver damage.

  • Nausea or vomiting
  • Stomach or belly pain
  • Fever
  • Weakness or unusual tiredness
  • Itching
  • Loss of appetite
  • Light-colored poop
  • Dark-colored urine
  • Your skin or the whites of your eyes turning yellowish in color (also called jaundice)

Precautions

Consult your pharmacist or physician.

Interactions

Does Paxlovid interact with foods or drinks?

There are no known interactions between Paxlovid and foods or drinks.

It is unknown if drinking alcohol will affect Paxlovid.

Does Paxlovid interact with other medicines (drug interactions)?

Paxlovid interacts with many other medicines. Always tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.

In particular, make sure that you discuss if you are using any of the following before taking Paxlovid.

  • Alfuzosin or silodosin, which is a medicine commonly used for a large prostate 
  • Colchicine, which is a medicine commonly used for gout
  • Ranolazine, which is a medicine commonly used for chest pain
  • Amiodarone, dronedarone, flecainide, propafenone, quinidine (and others), which is a medicine used for an irregular heart rhythm 
  • Eplerenone and finerenone, which is a medicine for the heart or blood pressure
  • Lurasidone or pimozide, which is a medicine for certain mental health conditions
  • Lovastatin, simvastatin, or lomitapide (and others), which is a medicine used to lower cholesterol 
  • Eletriptan or ubrogepant, which is a medicine commonly used for migraine
  • An ergot, such as ergotamine (Ergomar), dihydroergotamine (Migranal or Trudhesa) or methylergonovine, which is a medicine used to treat migraine
  • Carbamazepine or phenytoin, which is a medicine to control seizures
  • A barbiturate, such as phenobarbital or primidone, which is a medicine that may be used to treat insomnia, migraine, or seizures
  • Naloxegol, which is a medicine to block opioids
  • Midazolam (oral) or triazolam, which is a medicine commonly used for sleep or anxiety
  • Flibanserin, which is a medicine used for low sexual desire in women
  • Lumacaftor/ivacaftor, which is a medicine used for cystic fibrosis 
  • Rifampin or rifapentine, which is a medicine used to treat an infection called tuberculosis
  • A type of medicine called a phosphodiesterase-5 (PDE-5) inhibitor, such as sildenafil (Viagra, Revatio, and others), which is used for erectile dysfunction and pulmonary arterial hypertension (PAH)
  • Voclosporin, which is a medicine to suppress your immune system
  • Apalutamide, which is a medicine used to treat cancer
  • A birth control pill, patch, or ring
  • Tolvaptan, which is a medicine for your heart or kidneys
  • Ivabradine, which is a medicine for your heart
  • St. John’s wort, which is a supplement that may be used to treat depression

Paxlovid may alter the blood levels of many other medicines, and vice versa. Tell your healthcare provider about all medicines that you take or have recently taken.

This may not be a complete list of medicines that can interact with Paxlovid. Always check with your healthcare provider.

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Overdose

If someone has overdosed and has serious symptoms such as passing out or trouble breathing , call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

Notes Notes

No monograph available at this time.

Missed Dose Missed Dose

Consult your pharmacist or physician.

Storage Storage

Images

Paxlovid 150 mg-100 mg tablets in a dose pack (Renal Dose)

Paxlovid 150 mg-100 mg tablets in a dose pack (Renal Dose)

Color: multi-color (2)Shape: ovalImprint: PFE or logo and NK 3CL

This medicine is a multi-color (2), oval, film-coated, tablet imprinted with "PFE or logo and NK" and "3CL".

Paxlovid 150 mg-100 mg tablets in a dose pack (Renal Dose)

Paxlovid 150 mg-100 mg tablets in a dose pack (Renal Dose)

Color: multi-color (2)Shape: ovalImprint: PFE or logo and NK 3CL

This medicine is a multi-color (2), oval, film-coated, tablet imprinted with "PFE or logo and NK" and "3CL".

Paxlovid 300 mg (150 mg x 2)-100 mg tablets in a dose pack

Paxlovid 300 mg (150 mg x 2)-100 mg tablets in a dose pack

Color: multi-color (2)Shape: ovalImprint: PFE or logo and NK 3CL or blank

This medicine is a multi-color (2), oval, film-coated, tablet imprinted with "PFE or logo and NK" and "3CL".

Paxlovid 300 mg (150 mg x 2)-100 mg tablets in a dose pack

Paxlovid 300 mg (150 mg x 2)-100 mg tablets in a dose pack

Color: multi-color (2)Shape: ovalImprint: PFE or logo and NK 3CL or blank

This medicine is a multi-color (2), oval, film-coated, tablet imprinted with "PFE or logo and NK" and "3CL".

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.