Uses

This medication is used to treat prostate cancer. Lutetium Lu 177 vipivotide tetraxetan is a radioactive drug. It works by attaching to certain cancer cells and causing them to die.

How to use Pluvicto 27 Mci/Ml (1,000 Mbq/Ml) Intravenous Solution

This medication is given by injection into a vein by a health care professional. It is given as directed by your doctor, usually once every 6 weeks for up to 6 doses.

The dosage is based on your medical condition, lab tests, and response to treatment.

Drink plenty of fluids before and after treatment with this medication and urinate as often as possible to lessen damage to your bladder. Ask your doctor for more details.

To reduce radiation exposure to others after receiving this medication, avoid close contact (less than 3 feet) with people for 2 days and with children and pregnant women for 7 days. Do not have sexual activity for 7 days. Also, sleep in a different bedroom from other people for 3 days, from children for 7 days, and from pregnant women for 15 days. If you have any questions, ask your doctor or pharmacist.

Side Effects

Dizziness, tiredness, headache, nausea, vomiting, diarrhea/constipation, abdominal pain, change in how food tastes, dry mouth, or decreased appetite may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

To relieve dry mouth, suck (sugarless) hard candy or ice chips, chew (sugarless) gum, drink water, or use a saliva substitute.

People using this medication may have serious side effects. However, you have been prescribed this drug because your doctor has judged that the benefit to you is greater than the risk of side effects. Careful monitoring by your doctor may decrease your risk.

Tell your doctor right away if you have any serious side effects, including: signs of kidney damage (such as change in amount of urine).

This medication decreases bone marrow function, a severe (possibly fatal) effect that may lead to a low number of blood cells such as red cells, white cells, and platelets. This effect can cause anemia, decrease your body's ability to fight an infection, or cause easy bruising/bleeding. Tell your doctor right away if you develop any of the following unlikely symptoms: unusual tiredness, pale skin, signs of infection (such as sore throat that doesn't go away, fever, chills, painful/burning urination), easy bruising/bleeding.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before using lutetium Lu 177 vipivotide tetraxetan, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney problems.

This drug may make you dizzy. Alcohol or marijuana (cannabis) can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).

This medication can make you more likely to get infections or may worsen any current infections. Avoid contact with people who have infections that may spread to others (such as chickenpox, measles, flu). Consult your doctor if you have been exposed to an infection or for more details.

Tell your health care professional that you are using lutetium Lu 177 vipivotide tetraxetan before having any immunizations/vaccinations. Avoid contact with people who have recently received live vaccines (such as flu vaccine inhaled through the nose).

To lower the chance of getting cut, bruised, or injured, use caution with sharp objects like razors and nail cutters, and avoid activities such as contact sports.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

This medication may affect the ability to have children. Talk to your doctor for details.

Lutetium Lu 177 vipivotide tetraxetan should not be used by women, especially during pregnancy or breast-feeding. It may harm an unborn or breast-feeding baby. Men with female partners of childbearing age should ask about reliable forms of birth control while using this medication and for 14 weeks after the last dose. Consult your doctor if you have any questions about this medication.

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

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Overdose

If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

Notes

Lab and/or medical tests (such as complete blood count, kidney/liver function, blood mineral levels) should be done before you start receiving this medication and while you are using it. Keep all medical and lab appointments.

Missed Dose

It is important to get each dose of this medication as scheduled. If you miss a dose, ask your doctor or pharmacist right away for a new dosing schedule. Do not double the dose to catch up.

Storage

Not applicable. This medication is given in a hospital or clinic or doctor's office and will not be stored at home.

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Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.