Ticlopidine/Aspirin Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

When these two medicines are taken together, the effects of one or both medicines may increase.

What might happen:

You may experience an increased chance for bleeding.

What you should do about this interaction:

If you experience bleeding from your gums, nosebleeds, unusual bruising, dark stools, fever, chills, sore throat, weakness, paleness, or cough, contact your doctor.Your healthcare professionals (e.g. doctor or pharmacist) may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Ticlopidine hydrochloride US prescribing information. Teva Pharmaceuticals USA June, 2003.
  • 2.De Caterina R, Sicari R, Bernini W, Lazzerini G, Buti Strata G, Giannessi D. Benefit/risk profile of combined antiplatelet therapy with ticlopidine and aspirin. Thromb Haemost 1991 May 6;65(5):504-10.
  • 3.Thebault JJ, Blatrix CE, Blanchard JF, Panak EA. The interactions of ticlopidine and aspirin in normal subjects. J Int Med Res 1977; 5(6):405-11.
  • 4.Uchiyama S, Sone R, Nagayama T, Shibagaki Y, Kobayashi I, Maruyama S, Kusakabe K. Combination therapy with low-dose aspirin and ticlopidine in cerebral ischemia. Stroke 1989 Dec;20(12):1643-7.