Thiazide & Related Diuretics/Cholestyramine; Colestipol Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

When these two medicines are taken together, your body may not absorb your diuretic (water pill) properly.

What might happen:

Your diuretic (water pill) may not reduce the water in your body. This may cause water retention or an increase in your blood pressure.

What you should do about this interaction:

If you experience problems with your breathing, increased swelling, tiredness, weakness, headache, or dizziness, contact your healthcare professionals (e.g. doctor or pharmacist) about taking these two medicines together. Your doctor may instruct you to take these two medicines at two different times.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Kauffman RE, Azarnoff DL. Effect of colestipol on gastrointestinal absorption of chlorothiazide in man. Clin Pharmacol Ther 1973 Sep-Oct; 14(5):886-90.
  • 2.Hunninghake DB, King S. Effect of cholestyramine and colestipol on the absorption of methyldopa and hydrochlorothiazide. Pharmacologist 1978; 20:220.
  • 3.LaCroix K, King S, Hunninghake DB. Effect of dosing schedules of cholestyramine on the absorption of hydrochlorothiazide. Pharmacologist 1979;21:263.
  • 4.Hunninghake DB, King S, LaCroix K. The effect of cholestyramine and colestipol on the absorption of hydrochlorothiazide. Int J Clin Pharmacol Ther Toxicol 1982 Apr;20(4):151-4.
  • 5.Hunninghake DB, Hibbard DM. Influence of time intervals for cholestyramine dosing on the absorption of hydrochlorothiazide. Clin Pharmacol Ther 1986 Mar;39(3):329-34.
  • 6.Neuvonen PJ, Kivisto K, Hirvisalo EL. Effects of resins and activated charcoal on the absorption of digoxin, carbamazepine and frusemide. Br J Clin Pharmacol 1988 Feb;25(2):229-33.