Skip to content

    Phenytoin Suspension, (Final Dose Form)


    Hydantoins, Oral/Sucralfate

    This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

    Medical warning:

    Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

    How the interaction occurs:

    When these two medicines are taken together, your body may absorb less of your seizure medicine.

    What might happen:

    The effects of your seizure medicine may decrease.

    What you should do about this interaction:

    Contact your doctor if you experience any seizures.Your healthcare professionals (e.g. doctor or pharmacist) may already be aware of this drug interaction and may be monitoring you for it. It may be necessary to adjust the dosage of your seizure medicine. Do not start, stop, or change the dosage of any medicine before checking with them first.


    1.Smart HL, Somerville KW, Williams J, Richens A, Langman MJ. The effects of sucralfate upon phenytoin absorption in man. Br J Clin Pharmacol 1985 Sep; 20(3):238-40.

    2.Hall TG, Cuddy PG, Glass CJ, Melethil S. Effect of sucralfate on phenytoin bioavailability. Drug Intell Clin Pharm 1986 Jul-Aug;20(7-8):607-11.

    Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

    CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

    More about Drugs and Medications


    Subscribe to free WebMD newsletters.

    • WebMD Daily

      WebMD Daily

      Subscribe to the WebMD Daily, and you'll get today's top health news and trending topics, and the latest and best information from WebMD.

    • Men's Health

      Men's Health

      Subscribe to the Men's Health newsletter for the latest on disease prevention, fitness, sex, nutrition, and more from WebMD.

    • Women's Health

      Women's Health

      Subscribe to the Women's Health newsletter for the latest on disease prevention, fitness, sex, diet, anti-aging, and more from WebMD.

    By clicking Submit, I agree to the WebMD Terms & Conditions & Privacy Policy and understand that I may opt out of WebMD subscriptions at any time.

    URAC Seal TRUSTe Privacy Certification TAG seal HONcode Seal AdChoices