Acitretin/Methotrexate Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Very Serious. These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Both of your medicines can affect your liver.

What might happen:

You may have an increased risk of developing serious liver problems. Signs of liver problems may include yellowing of the skin or eyes or abdominal pain.

What you should do about this interaction:

Talk to your healthcare professionals (e.g. doctor or pharmacist) as soon as possible about taking these two medicines together. Contact your doctor if you notice any yellowing of your skin or eyes, or if you have any abdominal pain.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.McClure SL, Valentine J, Gordon KB. Comparative tolerability of systemic treatments for plaque-type psoriasis. Drug Saf 2002;25(13):913-27.
  • 2.Soriatane (acitretin) US prescribing information. Roche Pharmaceuticals February, 2014.
  • 3.Methotrexate sodium Inj. US prescribing information. Hospira Worldwide, Inc. March, 2018.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.