Lithium/Carbonic Anhydrase Inhibitors Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Carbonic anhydrase inhibitors may cause your kidneys to remove lithium from your blood more quickly.

What might happen:

The amount of lithium in your blood may decrease and it may not work as well.

What you should do about this interaction:

Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Your doctor may want to check the amount of lithium in your blood. Let your doctor know if you do not think that your lithium is working.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Thomsen K, Schou M. Renal lithium excretion in man. Am J Physiol 1968 Oct; 215(4):823-7.
  • 2.Horowitz LC, Fisher GU. Acute lithium toxicity. N Engl J Med 1969 Dec 11; 281(24):1369.