Moclobemide/Cimetidine Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Cimetidine may slow down how quickly your body removes moclobemide.

What might happen:

The amount of moclobemide in your blood may increase and cause side effects.

What you should do about this interaction:

Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Your doctor may want to change the dosage of your moclobemide while you are taking cimetidine or if you stop taking cimetidine. Let your doctor know if you have difficulty sleeping, increased anxiety, nausea, vomiting, drowsiness, disorientation, or seizures.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Arima (moclobemide) Australian prescribing information. Alphapharm Pty Ltd. March 27, 2000.
  • 2.Schoerlin MP, Mayersohn M, Hoevels B, Eggers H, Dellenbach M, Pfefen JP. Cimetidine alters the disposition kinetics of the monoamine oxidase-A inhibitor moclobemide. Clin Pharmacol Ther 1991 Jan;49(1):32-8.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.