Nilotinib/Possible QT Prolonging Agents Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Nilotinib may affect your heart's rhythm. Other drugs can have the same effect.

What might happen:

Taking nilotinib with agents that can affect your heart rhythm may increase your risk of an irregular heartbeat, which may be life-threatening.

What you should do about this interaction:

Contact your healthcare professionals (e.g doctor or pharmacist) about taking these medications together. Let your doctor know right away if you notice an irregular heartbeat or have dizziness or fainting episodes. Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Tasigna (nilotinib) US prescribing information. Novartis Pharmaceuticals Corporation February 21, 2017.
  • 2.Woosley RL, Romero KA. www.Crediblemeds.org, QTdrugs List, AZCERT, Inc. 1822 Innovation Park Dr., Oro Valley, AZ 85755. November 17, 2015.
  • 3.Tasigna (nilotinib) UK prescribing information. Novartis Pharmaceuticals Corporation May, 2008.
  • 4.Drew BJ, Ackerman MJ, Funk M, Gibler WB, Kligfield P, Menon V, Philippides GJ, Roden DM, Zareba W. Prevention of torsade de pointes in hospital settings: a scientific statement from the American Heart Association and the American College of Cardiology Foundation. J Am Coll Cardiol 2010 Mar 2;55(9):934-47.