The most common symptom of osteoarthritis is pain in the affected joints after repetitive use. Joint pain is usually worse later in the day. There can be swelling, warmth, and creaking of the affected joints. Pain and stiffness of the joints can also occur after long periods of inactivity, for example, sitting in a theater. In severe osteoarthritis, complete loss of cartilage causes friction between bones, causing pain at rest or pain with limited motion.
Osteoarthritis Health Center
FDA Panel OKs Stronger Opioid Despite Concerns
The company says there's a need for opioid pain medicines that don't require swallowing, because some patients have difficulty taking oral medication and may not have access to IV opioids. The FDA had earlier flagged two safety concerns.
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