Prescription Medications and Treatments for Nerve Pain

Medically Reviewed by Carol DerSarkissian, MD on May 14, 2022
6 min read

Getting control of your nerve pain can be tough. The good news is that doctors have a lot of effective ways to treat it. These include medicines, like prescription pain relievers or anticonvulsants and antidepressants, as well as electrical stimulation and other techniques.

So if you have nerve pain, whether it's caused by cancer, HIV, shingles, or another condition, take hope. Here's a rundown of the prescription treatments that your doctor might recommend.

There are several types of medication that help with nerve pain. However, not all of the ones listed here will necessarily work for your specific type of pain. The best choice for you depends on the cause of your pain, the severity, the potential side effects, and other factors.

  • Anticonvulsants. The name might sound alarming, but some of these drugs can help people with nerve pain. In fact, they're often considered a first choice. These drugs were originally developed for people with epilepsy to control seizures. It turned out that their effects on the nervous system could also help dull pain. Side effects may include drowsiness, dizziness, and nausea.

Keep in mind that not all anticonvulsants will help. So your doctor will choose medicines that have been shown in studies to work on nerve pain.

  • Antidepressants. Along with anticonvulsants, certain types of antidepressants can be the first choice for treating neuropathic pain. Nerve pain specialists often recommend two major types.
    • Tricyclic antidepressants have been used for decades. While they're not used as often today to treat depression, they can play an important role in controlling nerve pain symptoms. Many studies have shown that they can help. These drugs can cause side effects, like dizziness, constipation, blurred vision, and upset stomach. They might not be safe for people with certain conditions, like heart problems.
    • SNRIs (serotonin and norepinephrine reuptake inhibitors) are a newer type of antidepressant that seem to help with nerve pain. In general, these drugs have fewer side effects than tricyclic antidepressants. They might be safer for some, especially older people with heart problems. However, they might not be as effective as tricyclics in tackling nerve pain.

Using antidepressants for nerve pain can have an added benefit, considering that chronic pain often coincides with depression. Chronic pain can make a person depressed, and depression can often make the experience of chronic pain seem worse. So these drugs might help improve your mood, as well as ease your discomfort.

Of course, some people don't like the idea of taking antidepressants for their nerve pain because they worry taking antidepressants implies that the pain is just "in their heads." But that's not the case at all. It just happens that these drugs work with both conditions.

  • Painkillers. For severe nerve pain, powerful opioid painkillers can help. Studies have found that for many types of nerve pain, they are as effective as anticonvulsants or antidepressants. Unlike other treatments for nerve pain, they also work very quickly.
    However, because of their side effects, many doctors only turn to these drugs when other treatments haven't worked. Opioid painkillers can cause constipation, stomach upset, and sedation. They also pose some risk of addiction and abuse, so it's important to use them exactly as your doctor recommends.
    Other painkillers -- like prescription doses of NSAIDs (nonsteroidal anti-inflammatory drugs) -- might be helpful. But on the whole, those drugs don't seem to work well with nerve pain.
  • Topical treatments. Painkilling gels and lidocaine patches are another effective approach; you would apply them on a particularly painful area of skin. These work best with small, localized spots of pain. The side effects are minor and include skin irritation.
  • Combination treatments. Your doctor might recommend that you use one or two of these treatments together -- an approach called combination therapy. Many studies have shown that combining certain drugs -- often an anticonvulsant and an antidepressant -- has a better effect on nerve pain than either medications alone.


  • Watch out for interactions. Before you start taking a new medicine, make sure your doctor knows about every other prescription drug, OTC medicine, supplement, and vitamin you use. You might want to write them all down and bring in the list to your appointment -- or even bring the pill bottles with you instead.
  • Always follow your doctor's instructions for taking a new medicine. Make sure you understand how often you take it, how much you take, what time of day you should take it, and whether you should take it with or without food. Never stop using a prescription medicine without talking to your doctor first.
  • Don't ignore side effects. Talk to your doctor about them. They might be able to alter the dose or change the medicine to resolve the problem.

While medications are typically the first choice for neuropathic pain, some other approaches might help too. Here are some nondrug options.

Electrical stimulation. When you feel nerve pain, an electrical signal is being sent from a damaged nerve to your brain. Some treatments for nerve pain work by sending out their own electrical impulses. These charges seem to interrupt or block the pain signals, reducing the pain you feel.

  • TENS (transcutaneous electrical nerve stimulation) is one example of this approach. A small device sends a mild electric current through your skin. While TENS is simple and painless, the evidence that it helps with nerve pain is mixed. However, recent studies do seem to show that it can help with diabetic nerve pain, so the American Academy of Neurology does recommend it.
  • PENS (percutaneous electrical nerve stimulation ) -- also called electroacupuncture -- delivers electrical stimulation to the nerves through acupuncture needles. The American Academy of Neurology deems this probably effective in treating diabetic nerve pain, but the treatment is not widely available.
  • rTMS (repetitive transcranial magnetic stimulation) uses magnets to send electrical impulses into the brain. While evidence is limited, studies suggest that PENS and rTMS may help with nerve pain.

Other methods of electrical stimulation are more complex and require surgery. For instance, spinal cord stimulation involves implanting a device in the body that sends out electrical impulses to the spinal cord. For deep brain stimulation (DBS), a surgeon would implant electrodes in the brain. Generally, doctors only use these invasive approaches when everything else has failed.

Nerve pain can be hard to control. Some studies suggest that many people with nerve pain are not getting sufficient pain relief.

However, that doesn't mean you have to accept a life in pain. Experts believe that many of those people in pain could be helped. It's just that they aren't getting the proper treatment. They might be relying on medications that don't work. Or they might be getting the right drugs at the wrong dose.

So, if you're suffering with nerve pain and treatment isn't helping enough, don't give up hope. Instead, go back to your doctor and come up with a new approach. Or get a referral to an expert -- like a pain specialist or a neurologist.

There are a lot of different ways to tackle nerve pain. If one approach doesn't work, others might. By working with an expert, and being persistent, you can find something that will help.