Medically Reviewed by Minesh Khatri, MD on January 15, 2022
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Being intimate with your partner is one of life’s greatest pleasures. But a long-term health problem can take the joy out of sex. You may not want to have it, can’t get aroused enough, or have trouble reaching orgasm. Knowing what the problem is could be the first step to finding solutions.




High blood sugar damages blood vessels and nerves over time. This can hinder blood flow to your sex organs. Men can have erection and ejaculation problems. Women may have loss of desire, vaginal dryness, painful intercourse, and orgasm troubles. If you control your diabetes, stay active, and eat right, it can help keep sexual and other problems at bay. If they keep happening, tell your doctor about it.

Heart Disease

Heart Disease


As with diabetes, the problem is blood vessel damage that can lead to sexual problems. And some meds, such as those for high blood pressure, can cause issues as well. Lifestyle changes -- your diet and fitness, especially -- can make a big difference. If you’ve had a heart attack and worry that sex could trigger another one, ask your doctor about when you can be sexually active again.




Your mind and body go hand in hand. One of the symptoms of depression can be a drop in your sex drive. Tell your doctor or a therapist if you’ve been feeling down for a while. Treatment -- which may include talking with a counselor, making lifestyle changes, and medicine -- can help. Some antidepressants can dim desire and lead to erection problems in men. Lowering the dose or switching meds may help.




Sex may be the last thing on your mind when you have cancer. But when you are ready to be intimate, the disease and some of the treatments can make that harder to do. Chemo may make you too tired or sick for sex. You might have pain from the cancer. Hormone therapies may affect your sex drive. And some surgeries may affect your body image. Connect in other ways until you’re ready for sex.

Chronic Pain

Chronic Pain


It’s hard to think about sex, let alone do it, if you have pain that won’t quit. If your medications don’t control your pain well, your doctor may need to change the dose or switch meds. Or the medicine may be the problem. Some pain meds have sexual side effects because they affect your nervous system. Either way, talk to your doctor.




Sore joints and other arthritis symptoms can cramp your sex life. But you can still be intimate and comfortable if you think ahead:

  • Plan sex for the time of the day when you normally feel your best.
  • Take your pain medicine at least 30 minutes beforehand.
  • Support your joints with pillows or rolled sheets.
  • Use massage to soothe sore muscles and joints and as foreplay.
  • Nap before sex if tiredness is a problem.
Low Testosterone (Low T)

Low Testosterone (Low T)


Men who don’t make enough of the male hormone testosterone may find that their sex drive is stuck in neutral. Sometimes, it’s due to a problem in brain areas that tell the testes to make testosterone. Type 2 diabetes and liver or kidney disease also make it more likely. Your doctor may give you a blood test to check for these. Lifestyle changes and taking care of any other conditions you have can help. Some men may need testosterone replacement.




Natural menopause, the time in a woman’s life is when estrogen levels drop and periods have stopped, isn't a medical condition. But falling estrogen can cause vaginal drying and thinning. That can make sex hurt. Vaginal moisturizers and lubricants can help. Low-dose estrogen you put inside your vagina reverses dryness and thinning. If you have bad hot flashes too, hormone replacement therapy may be an option. Talk with your doctor about the pros and cons.




HIV affects your body’s ability to make hormones. This includes testosterone and estrogen, which can lead to problems with sex and desire.  Medications that keep the virus in check can hamper your sex life, too. Protease inhibitors are linked to erectile dysfunction in men. Your doctor may suggest counseling or other treatments.

Multiple Sclerosis (MS)

Multiple Sclerosis (MS)


MS affects your nervous system. Sexual desire begins in the brain.  It sends messages to the rest of your body via nerves that run down the spinal cord. If MS damages these paths, it can affect movement, arousal, and orgasm. It also can make you tired and give you muscle spasms. But there may be treatments that can help, so tell your doctor what’s going on.

Parkinson’s Disease

Parkinson’s Disease


Because it affects movement, Parkinson’s can make sex tough. It can also bring lack of desire, pain, and orgasm problems. Some of the treatments can cause the opposite problem. Meds that raise levels of a brain chemical called dopamine can make it harder to control your impulses, which for some people can cause problems including sex addiction. Your doctor may need to adjust your dose.

Loss of Bladder Control

Loss of Bladder Control


This is more common in seniors, especially women. Extra pressure on your belly during sex may make you leak urine. You may avoid intimacy. Try changing positions and going to the bathroom before sex.  Talk to your doctor, as treatment usually can help.

Inflammatory Bowel Disease (IBD)

Inflammatory Bowel Disease (IBD)


If you have Crohn’s disease or colitis, the digestive symptoms (such as needing to go to the bathroom a lot), pain, and fatigue can all get in the way of sex. It’s important to take your medicines as directed, even when your symptoms aren’t bad, so that you can continue to feel your best. Some people need intestinal surgery to make a way for their stool to collect in a bag worn outside of the body. Support groups or therapy can help you adjust to these changes.

PTSD (Posttraumatic Stress Disorder)

PTSD (Posttraumatic Stress Disorder)


PTSD can happen if you’ve had or seen a scary event like an assault, a bad car wreck, or combat. Symptoms include flashbacks, which feel like you’re reliving the trauma. If you have PTSD, you may feel fear instead of pleasure. A mental health expert with experience in PTSD can help. Talk therapy and medications may treat it successfully.

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National Institute of Diabetes and Digestive and Kidney Diseases: “Diabetes & Sexual & Urologic Problems.”

Cleveland Clinic: “Sexual Dysfunction and Disease.”

University of Texas Southwestern Medical Center: “Having sex after a heart attack - what you need to know.”

American Cancer Society: “How Cancer Affects Sexuality.”

Mayo Clinic: “Chronic Pain Can Interfere with Sexuality.”

American College of Rheumatology: “Sex and Arthritis.”

International Society for Sexual Medicine: “What is low testosterone?  What are the symptoms and how is it diagnosed?”

Hormone Health Network: “Low Testosterone.” 

The North American Menopause Society: “Effective Treatments for Sexual Problems.”

The Well Project: “Hormones and HIV.”

AIDS: “Risk factors for sexual and erectile dysfunction in HIV-infected men: the role of protease inhibitors.”

National Multiple Sclerosis Society: “Sexual Problems.”

The Michael J. Fox Foundation: “Parkinson’s Disease Symptoms,” “Sexual and Reproductive Health with Parkinson’s.”

Gastroenterology and Hepatology: “Inflammatory Bowel Disease and Sexual Dysfunction.”

U.S. National Library of Medicine: “Post-Traumatic Stress Disorder.”

International Society for Sexual Medicine: “PTSD and Sexual Dysfunction in Men and Women.”

Anxiety and Depression Association of America: “Treatment for PTSD.”