Most people don't notice the early symptoms of syphilis. The USPSTF recommends screening for syphilis infection in persons who are at increased risk for infection. Without treatment, it can lead to paralysis, blindness, and death. Syphilis can be cured with antibiotics.
Signs and Symptoms: The first sign is usually a firm, round, painless sore on the genitals or anus. The disease spreads through direct contact with this sore. Later there may be a rash on the soles, palms, or other parts of the body (seen here), as well as swollen glands, fever, hair loss, or fatigue. In the late stage, symptoms come from damage to organs such as the heart, brain, liver, nerves, and eyes.