Your doctor may also suggest a medicine (in the form of a pill) that targets your immune system.
Options include apremilast (Otezla), cyclosporine (Sandimmune), deucravacitinib (Sotyktu), and methotrexate (Rheumatrex, Trexall, Xatmep). Serious side effects are possible, so you'll need to be checked by your doctor carefully. Certain oral retinoids can also be used to treat severe psoriasis.
Biologics are a relatively new way to treat psoriasis. These drugs are made from living cells. Like some older psoriasis medications, they change the way your immune system behaves. You take biologics through an injection, pill, or IV. They work by curbing your immune system, so they can raise your risk of infections.