Fungal Infections: Risks of Oral Antifungals - Topic Overview

Oral antifungal medicines may be used to treat a fungal infection, such as athlete's foot or a fungal nail infection. Before you decide to take this type of medicine, you and your doctor will want to consider the risks. Some antifungal medicines may:

  • Affect liver or kidney function.
  • Cause liver damage or failure, especially when combined with alcohol or certain medicines.
  • Weaken the heart's ability to contract. This can lead to heart failure.
  • Cause dangerous side effects when combined with many common medicines.

During oral antifungal treatment, your doctor may require blood tests to check your kidney and liver function.

Mild side effects caused by these medicines may include stomach upset, headaches, and skin rash.

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