The cause of
chronic kidney disease isn't always known. But any
condition or disease that damages blood vessels or other structures in the
kidneys can lead to kidney disease. The most common causes of chronic kidney
High blood sugar
levels caused by diabetes damage blood vessels in the kidneys. If the blood
sugar level remains high over many years, this damage gradually reduces the function of the
High blood pressure (hypertension). Uncontrolled high blood pressure damages blood vessels, which can lead to damage in the kidneys. And blood pressure often rises with chronic kidney disease,
so high blood pressure may further damage kidney function even when another
medical condition initially caused the disease.
Other conditions that can damage the kidneys and cause
chronic kidney disease include:
Glomerulosclerosis refers to scarring or hardening of the glomeruli -- blood vessels located in the kidneys. The glomeruli filter the blood as it passes through the kidneys. They remove waste fluids that then leave the body as urine.
Damaged glomeruli can't perform their job adequately. As a result, large amounts of protein from the blood leak into the urine rather than remaining in the bloodstream. This leads to a condition called proteinuria.
Glomerulosclerosis can affect children and adults...
Diabetes and high blood pressure are the most common causes
of chronic kidney disease that leads to
kidney failure. Diabetes or high blood pressure may
also speed up the progression of chronic kidney disease in someone who already
has the disease.