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Chronic Kidney Disease

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What Happens

At first with chronic kidney disease, your kidneys are still able to regulate the balance of fluids, salts, and waste products in your body. But as kidney function decreases, you will start to have other problems, or complications. The worse your kidney function gets, the more complications you'll have and the more severe they will be.

When kidney function falls below a certain point, it is called kidney failure. Kidney failure has harmful effects throughout your body. It can cause serious heart, bone, and brain problems and make you feel very ill.

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Glomerulosclerosis

Glomerulosclerosis refers to scarring or hardening of the glomeruli -- blood vessels located in the kidneys. The glomeruli filter the blood as it passes through the kidneys. They remove waste fluids that then leave the body as urine. Damaged glomeruli can't perform their job adequately. As a result, large amounts of protein from the blood leak into the urine rather than remaining in the bloodstream. This leads to a condition called proteinuria. Glomerulosclerosis can affect children and adults...

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After you have kidney failure, either you will need to have dialysis or you will need a new kidney. Both choices have risks and benefits.

Complications of chronic kidney disease

  • AnemiaAnemia. You may feel weak, have pale skin, and feel tired, because the kidneys can't produce enough of the hormone (erythropoietin) needed to make new red blood cells.
  • Electrolyte imbalanceElectrolyte imbalance. When the kidneys can't filter out certain chemicals, such as potassium, phosphate, and acids, you may have an irregular heartbeat, muscle weakness, and other problems.
  • Uremic syndromeUremic syndrome. You may be tired, have nausea and vomiting, not have an appetite, or not be able to sleep when substances build up in your blood. The substances can be poisonous (toxic) if they reach high levels. This syndrome can affect many parts of your body, including the intestines, nerves, and heart.
  • Heart disease. Chronic kidney disease speeds up hardening of the arteries (atherosclerosis) and increases the risk of stroke, heart attack, and heart failure. Heart disease is the most common cause of death in people with kidney failure.
  • Bone disease (osteodystrophy). Abnormal levels of substances, such as calcium, phosphate, and vitamin D, can lead to bone disease.
  • Fluid buildup (edema). As kidney function gets worse, fluids and salt build up in the body. Fluid buildup can lead to heart failure and pulmonary edema.
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WebMD Medical Reference from Healthwise

Last Updated: August 29, 2013
This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.
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