When the body has too much cortisol, it can cause Cushing's syndrome. Initial symptoms may include weight gain and fatigue, but it can lead to more serious conditions, such as diabetes and osteoporosis. Steroids or tumors may cause the increase in cortisol. Treatments will depend on what has caused it. Tumors should be removed and a doctor can help you come off of steroids at a healthy pace. Follow the links below to find WebMD's comprehensive coverage about how Cushing's syndrome is contracted, how to treat it, and more.