Creatinine is a waste product from the normal breakdown of muscle tissue. As creatinine is produced, it's filtered through the kidneys and excreted in urine. Doctors measure the blood creatinine level as a test of kidney function. The kidneys' ability to handle creatinine is called the creatinine clearance rate, which helps to estimate the glomerular filtration rate (GFR) -- the rate of blood flow through the kidneys.
Goodpasture syndrome initially causes vague symptoms such as fatigue. But it can rapidly involve the lungs and kidneys. It is almost always fatal if it is not quickly diagnosed and treated.
Causes of Goodpasture Syndrome
Researchers do not fully understand why the immune system attacks collagen in the lungs and kidneys. Goodpasture syndrome can run in families. So some researchers believe it may have a genetic component.
Other factors that may increase the risk of Goodpasture syndrome include:
Exposure to certain chemicals, such as hydrocarbon solvents and the weed killer paraquat
Although Goodpasture syndrome may cause life-threatening bleeding in the lungs, it usually does not result in long-term lung damage. The most serious consequence of Goodpasture syndrome is kidney failure, which may require either dialysis or a kidney transplant.