Skip to content
Font Size
A
A
A

Goodpasture Syndrome

Goodpasture syndrome is a rare but serious autoimmune disease that attacks the lungs and kidneys.

The disease occurs when the body's immune system mistakenly produces antibodies against collagen in the lungs and kidneys. Collagen is a protein that helps form connective tissue.

Recommended Related to

10 Questions to Ask Your Doctor About Kidney Failure

If you were recently diagnosed with kidney failure, ask your doctor these questions at your next visit. What caused my kidney failure? Do I have hypertension, diabetes, or other disorders that may worsen my kidney failure? If I have an acute kidney problem, do you expect me to recover, and how long might that take? If my kidney problem is chronic, how long can I continue without dialysis, or will I ever need dialysis? What type of dialysis do you recommend? Am I a good ...

Read the 10 Questions to Ask Your Doctor About Kidney Failure article > >

Goodpasture syndrome initially causes vague symptoms such as fatigue. But it can rapidly involve the lungs and kidneys. It is almost always fatal if it is not quickly diagnosed and treated.

Causes of Goodpasture Syndrome

Researchers do not fully understand why the immune system attacks collagen in the lungs and kidneys. Goodpasture syndrome can run in families. So some researchers believe it may have a genetic component.

Other factors that may increase the risk of Goodpasture syndrome include:

  • Exposure to certain chemicals, such as hydrocarbon solvents and the weed killer paraquat
  • Exposure to metallic dust
  • Use of certain drugs, such as cocaine
  • Tobacco smoking
  • Viral infections

Goodpasture syndrome usually affects young men. It more often occurs among whites, and it most commonly affects people who are:

  • Between ages 20 and 30
  • Older than age 60

Symptoms of Goodpasture Syndrome

The first signs of Goodpasture syndrome may include:

Because Goodpasture syndrome may rapidly involve the lungs, initial symptoms such as shortness of breath can quickly progress to a persistent cough, sometimes with blood.

When Goodpasture syndrome affects the kidneys, symptoms may include:

Although Goodpasture syndrome may cause life-threatening bleeding in the lungs, it usually does not result in long-term lung damage. The most serious consequence of Goodpasture syndrome is kidney failure, which may require either dialysis or a kidney transplant.

Hot Topics

WebMD Video: Now Playing

Click here to wach video: Dirty Truth About Hand Washing

Which sex is the worst about washing up? Why is it so important? We’ve got the dirty truth on how and when to wash your hands.

Click here to watch video: Dirty Truth About Hand Washing

Popular Slideshows & Tools on WebMD

disciplining a boy
Types, symptoms, causes.
psoriasis
Does your kid have symptoms?
fruit drinks
Eat these to think better.
No gym workout
Moves to help control blood sugar.
acupuncture needle on shoulder
10 tips to look and feel good.
Close up of eye
12 reasons you're distracted.
Epinephrine Injection using Auto-Injector Syringe
Life-threatening triggers.
woman biting a big ice cube
Habits that wreck your teeth.
embarrassed woman
Do you feel guilty after eating?
pacemaker next to xray
Treatment options.
caregiver with parent
10 tips for daily life.
birth control pills
Which kind is right for you?

Pollen counts, treatment tips, and more.

It's nothing to sneeze at.

Loading ...

Sending your email...

This feature is temporarily unavailable. Please try again later.

Thanks!

Now check your email account on your mobile phone to download your new app.

Women's Health Newsletter

Find out what women really need.