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Understanding Kidney Disease -- the Basics

What Is Kidney Disease?

The kidneys are two organs located on either side of your spine in the middle of your back, just above the waist. They perform several life-sustaining roles: They cleanse your blood by removing waste and excess fluid, maintain the balance of salt and minerals in your blood, and help regulate blood pressure.

When the kidneys become damaged, waste products and fluid can build up in the body, causing swelling in your ankles, vomiting, weakness, poor sleep, and shortness of breath. If left untreated, diseased kidneys may eventually stop functioning completely. Loss of kidney function is a serious -- and potentially fatal -- condition.

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Autosomal Dominant Polycystic Kidney Disease

Autosomal dominant polycystic kidney disease (ADPKD) causes a lot of fluid-filled sacs, called cysts, to grow in your kidneys. The cysts keep your kidneys from working like they should. That can cause health problems like high blood pressure, infections, and kidney stones. It can also cause kidney failure, although that doesn't happen to everyone. You can have ADPKD and not know it for many years. It’s often called “adult PKD,” because the symptoms don't usually appear until people reach ages 30...

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Healthy kidneys handle several specific roles. Healthy kidneys:

  • Maintain a balance of water and concentration of minerals, such as sodium, potassium, and phosphorus, in your blood
  • Remove waste by-products from the blood after digestion, muscle activity, and exposure to chemicals or medications
  • Produce renin, an enzyme that helps regulate blood pressure
  • Produce erythropoietin, which stimulates red blood cell production
  • Produce an active form of vitamin D, needed for bone health

 

What Causes Acute Kidney Injury?

The sudden loss of kidney function is called acute kidney injury, also known as acute renal failure (ARF). ARF can occur following:

  • A traumatic injury with blood loss
  • The sudden reduction of blood flow to the kidneys
  • Damage to the kidneys from shock during a severe infection called sepsis
  • Obstruction of urine flow, such as with an enlarged prostate
  • Damage from certain drugs or toxins
  • Pregnancy complications, such as eclampsia and pre-eclampsia, or related HELLP Syndrome

Marathon runners and other athletes who don't drink enough fluids while competing in long-distance endurance events may suffer acute renal failure due to a sudden breakdown of muscle tissue. This muscle breakdown releases a chemical called myoglobin that can damage the kidneys.

 

 

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