Individual differences in the way your body
produces or gets rid of uric acid.
Conditions, such as:
Kidney disease or kidney
The increased breakdown of body cells that occurs with some
types of cancer (including
multiple myeloma) or cancer treatments,
sickle cell anemia, or
Other disorders, such as
preeclampsia, liver disease (cirrhosis),
hypothyroidism, and low blood levels of
A rare inherited gene disorder called Lesch-Nyhan
Medicines, such as some
diuretics, vitamin C (ascorbic acid), lower doses of
aspirin (75 to 100 mg daily), niacin, warfarin (such as Coumadin),
cyclosporine, levodopa, tacrolimus, and some medicines used to treat
Eating foods that are very high in
purines, such as organ meats (liver, brains), red
meats (beef, lamb), game meat (deer, elk), some seafood (sardines, herring,
scallops), and beer.
Low uric acid values may be caused
Severe liver disease,
Wilson's disease, or some types of
The syndrome of inappropriate antidiuretic hormone (SIADH),
a condition that causes large amounts of fluid to build up in the
Not eating enough protein.
amounts of aspirin (1,500 mg or more daily), probenecid (such as Probalan), and
allopurinol (such as Zyloprim).
What To Think About
Having a high uric acid level does not mean
that you have gout. If your uric acid level is high and you do not have any
other symptoms, you will not need to take any medicine to decrease your uric
A high level of uric acid in the blood does not always
mean that a person with a painful joint has gout. Testing the fluid taken from
an affected joint for the presence of uric acid crystals is the only sure
method to diagnose gout. To learn more, see the topic
Joint Fluid Analysis.
Uric acid may also
be measured in urine. If your blood uric acid level is high, a 24-hour urine
collection may help your doctor find out whether your body is producing too much uric acid
or your kidneys are not getting rid of enough of it. To learn more, see
Uric Acid in Urine.
Uric acid blood levels
vary from day to day. The level is usually higher in the morning and lower in
Blood uric acid levels that increase during pregnancy,
even if the levels remain within the normal range, may help diagnose