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    Stage III Breast Cancer Treatment Options

    In stage III, the cancer has spread beyond the breast and into nearby lymph nodes. Usually many lymph nodes have cancer cells, or the tumor is so large it grows into the chest wall or skin of the breast. A combination of different treatments often works best.


    Chemotherapy is a common treatment for stage III breast cancer. Sometimes people have chemo before surgery to shrink a tumor and make it easier to remove. You’d still have it after surgery as well. It can help destroy cancer cells that remain after surgery. In cases where surgery isn't an option, chemotherapy may be the main treatment.

    You can get chemo several different ways. You may take pills or liquids, but often the drugs are put right into your veins. Depending on the type of treatment, it may be given in cycles that allow your body breaks in between.

    Surgery. You might get a lumpectomy, in which a surgeon removes the tumor and some surrounding tissue from the breast. Or you might need a mastectomy, in which the whole breast is removed. The surgeon would also remove lymph nodes. After a mastectomy, you might choose to get breast reconstruction surgery.

    Radiation therapy is often recommended for women with stage III following surgery. The treatment can destroy cancer cells that may have been missed.

    Hormone therapy can help women with hormone receptor-positive cancers. That means the cancer needs hormones to grow. In these women, medications can prevent the tumor from getting the hormone. These drugs include tamoxifen for all women and anastrozole (Arimidex), exemestane (Aromasin), and letrozole (Femara) for postmenopausal women.

    Women who haven't reached menopause may consider having their ovaries removed to stop them from making hormones that help cancer grow. Medications can also stop the ovaries from releasing hormones.

    Targeted therapy is a newer treatment. About 20% of women with breast cancer have too much of a protein known as HER2, and it makes the cancer spread quickly. Women with HER2-positive cancer may be prescribed ado-trastuzumab emtansine (Kadcyla), lapatinib (Tykerb), pertuzumab (Perjeta), or trastuzumab (Herceptin). These medications can stop this protein from making the cancer grow and can make chemotherapy more effective.

    Clinical trials are something else to consider. They’re open to many women with stage III breast cancer and may give you access to cutting-edge treatments. Talk to your doctor for more information about joining one.

    WebMD Medical Reference

    Reviewed by Melinda Ratini, DO, MS on June 23, 2015

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