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Wilms Tumor and Other Childhood Kidney Tumors Treatment (PDQ®): Treatment - Health Professional Information [NCI] - Changes to This Summary (11 / 27 / 2012)

The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above.

General Information

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Added text about the results of an analysis of Wilms tumor patients in the Surveillance, Epidemiology and End Results database that found that adults had a statistically worse overall survival than pediatric patients. Also added text to state that the investigators recommended that all adult patients diagnosed with Wilms tumor should undergo lymph node sampling and that there should be close collaboration with pediatric surgeons and oncologists in treatment planning (cited Kalapurakal et al. as reference 9, Reinhard et al. as reference 10, and Ali et al. as reference 11).

Cellular Classification

Added text to state that while little is known about the biology of clear cell sarcoma of the kidney, the t(10;17)(q22;p13) translocation has been reported in clear cell sarcoma of the kidney. As a result of the translocation, the YWHAE-FAM22 fusion transcript is formed; this was detected in 12% of clear cell sarcoma of the kidney cases in one series (cited O'Meara et al. as reference 16).

Treatment of Wilms Tumor

Added text about the results from a series of 49 patients with Wilms tumor who received preoperative therapy according to the SIOP-93-01 guidelines, and how the timing of surgery was determined when there was no longer imaging evidence of tumor regression (cited Sudour et al. as reference 15).

Added Adults with Wilms tumor as a new subsection.

This summary is written and maintained by the PDQ Pediatric Treatment Editorial Board, which is editorially independent of NCI. The summary reflects an independent review of the literature and does not represent a policy statement of NCI or NIH. More information about summary policies and the role of the PDQ Editorial Boards in maintaining the PDQ summaries can be found on the About This PDQ Summary and PDQ NCI's Comprehensive Cancer Database pages.

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WebMD Public Information from the National Cancer Institute

Last Updated: February 25, 2014
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