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    CFS Linked to Childhood Trauma

    Study Shows Sexual or Emotional Abuse May Be Risk Factor for Chronic Fatigue Syndrome
    WebMD Health News
    Reviewed by Louise Chang, MD

    Jan. 5, 2009 -- Experiencing serious trauma during childhood may increase a person's risk for developing chronic fatigue syndrome later in life, a new study suggests.

    In the study from the CDC and Atlanta's Emory University, patients with chronic fatigue syndrome (CFS) reported much higher levels of childhood trauma than people without the disorder.

    Severe childhood trauma -- including sexual abuse, emotional abuse, and neglect -- was associated with a sixfold increase in CFS.

    Chronic fatigue syndrome remains a poorly understood disorder, and the suggestion that early-life stresses play an important role in the disease remains controversial.

    Harvard Medical School professor and CFS expert Anthony L. Komaroff, FACP, did not take part in the new study. But he tells WebMD that the findings make a strong case for childhood trauma altering brain chemistry in a way that makes some people more vulnerable to CFS.

    "These researchers are definitely not saying that early-life trauma is the cause of chronic fatigue syndrome," he says. "To say that something is a risk factor is very different from saying that it is the cause."

    Childhood Trauma and CFS

    The newly reported study builds on previous research from the CDC and Emory team, which first suggested the link between early-life trauma and an increased risk for CFS.

    CDC estimates suggest that as many as 2.5% of American adults have CFS, even though many have not been diagnosed.

    In that study, researchers examined and interviewed 43 CFS patients and 60 people without the disorder living in Wichita, Kan.

    Self-reported childhood trauma was associated with a three- to eightfold increased risk for CFS, with the highest risk seen in patients who had suffered from more than one early-life trauma.

    The new study involved 113 CFS patients and 124 people without the disorder living in urban, suburban, or rural Georgia.

    In addition to interviews to determine whether study participants had experienced childhood trauma, all participants underwent screening for depression, anxiety, and posttraumatic stress disorder.

    The interviews revealed that:

    • 62% of CFS patients reported being the victims of severe childhood traumas compared to 24% of study participants without CFS.
    • 33% of CFS patients reported a childhood history of sexual abuse, compared to nearly 11% of study participants without CFS.
    • 33% of CFS patients reported being the victims of emotional abuse, compared to 7% of study participants without CFS.

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